| Autor: |
Kee Yuan Ngiam, Michele I. Morris, Lav P Patel, Chuan Hong, Andrew M South, Trang T. Le, Emily Schriver, Jiyeon Son, Yuan Luo, Jason H. Moore, Zongqi Xia, Paul Avillach, Brett K Beaulieu-Jones, Shyam Visweswaran, Malarkodi J Samayamuthu, Tianxi Cai, Isaac S. Kohane, Amelia Lm Tan, Ne Hooi Will Loh, Gilbert S. Omenn, Danielle L. Mowery, Alba Gutiérrez-Sacristán |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
medRxiv |
| DOI: |
10.1101/2021.01.27.21249817 |
| Popis: |
OBJECTIVENeurological complications can worsen outcomes in COVID-19. We defined the prevalence of a wide range of neurological conditions among patients hospitalized with COVID-19 in geographically diverse multinational populations.METHODSUsing electronic health record (EHR) data from 348 participating hospitals across 6 countries and 3 continents between January and September 2020, we performed a cross-sectional study of hospitalized adult and pediatric patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test, both with and without severe COVID-19. We assessed the frequency of each disease category and 3-character International Classification of Disease (ICD) code of neurological diseases by countries, sites, time before and after admission for COVID-19, and COVID-19 severity.RESULTSAmong the 35,177 hospitalized patients with SARS-CoV-2 infection, there was increased prevalence of disorders of consciousness (5.8%, 95% confidence interval [CI]: 3.7%-7.8%,pFDRpFDRINTERPRETATIONUsing an international network and common EHR data elements, we highlight an increase in the prevalence of central and peripheral neurological phenotypes in patients hospitalized with SARS-CoV-2 infection, particularly among those with severe disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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