Structural Neuroimaging Studies in Late-Life Depression: A Review
| Autor: | David Ames, Isaac Schweitzer, John T. O'Brien, Virginia Tuckwell |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Caudate nucleus Hippocampus Basal Ganglia Cerebral Ventricles Atrophy Neuroimaging medicine Humans Dementia Psychiatry Biological Psychiatry Depression (differential diagnoses) Aged Depressive Disorder Major Brain Late life depression medicine.disease Magnetic Resonance Imaging Hyperintensity Frontal Lobe Psychiatry and Mental health Frontal lobe Female Caudate Nucleus Psychology |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1814-1412 1562-2975 |
| DOI: | 10.3109/15622970109027497 |
| Popis: | Which patients presenting with depression in late life will progress to a dementia syndrome has been an important research question in recent times. In this paper we review selectively structural neuroimaging investigations of late-life depression (LLD) that have been performed over the past two decades. These studies indicate that there are neuroimaging changes commonly observed in LLD patients when compared to normal controls. Findings include ventricular enlargement and sulcal widening, and reduction in volume size of frontal lobes, hippocampus and caudate nucleus. White matter lesions are more common in depressed subjects and tend to be more severe. Some studies report these changes to be more pronounced in patients who present with late-onset depression (LOD) but this has been contradicted by other studies. Preliminary work suggests that these changes may be associated with a poor prognosis but there is a dearth of systematic, well-controlled longitudinal studies. |
| Databáze: | OpenAIRE |
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