Interrelationships of factor VII activity and plasma leptin with insulin resistance in coronary heart disease
Autor: | Gurmukh S. Sainani, Rubina A. Karatela |
---|---|
Rok vydání: | 2010 |
Předmět: |
Adult
Leptin Male medicine.medical_specialty medicine.medical_treatment Blood lipids Coronary Disease Insulin resistance Internal medicine Blood plasma medicine Humans cardiovascular diseases business.industry Insulin Factor VII Middle Aged medicine.disease Endocrinology Blood pressure Female Insulin Resistance Cardiology and Cardiovascular Medicine business Body mass index Dyslipidemia |
Zdroj: | Atherosclerosis. 209:235-240 |
ISSN: | 0021-9150 |
DOI: | 10.1016/j.atherosclerosis.2009.08.043 |
Popis: | Objective An increase of FVII activity (FVIIc) has been proposed to be an independent cardiovascular risk factor. Whether FVII is associated with insulin resistance in coronary heart disease (CHD) is still unknown. We tested the hypothesis that plasma FVII activity and leptin are associated with insulin resistance independently. Methods We studied 130 subjects, of which 65 were CHD subjects and 65 were non-CHD control subjects. Fasting plasma levels of leptin, insulin, glucose, FVIIc activity, fibrinogen, lipid parameters were estimated for all the subjects. Body mass index (BMI), waist circumference (WC) and blood pressure levels were also determined. Results We observed significantly raised plasma levels of FVIIc activity, leptin and insulin resistance among the CHD subjects compared to the non-CHD subjects. Raised FVIIc activity levels in CHD were significantly positively correlated with insulin resistance. Raised plasma leptin levels in CHD were correlated with insulin resistance, BMI and WC. Multivariate regression analysis showed that elevated levels of FVII activity in CHD was significantly associated with insulin resistance, independent of dyslipidemia, leptin, blood pressure levels, BMI, WC, gender and age. Furthermore, raised leptin levels in CHD subjects were significantly associated with insulin resistance and BMI, independently of each other and of dyslipidemia, FVIIc, blood pressure levels, WC, gender and age. Conclusion Raised FVII and leptin levels in CHD patients were independently associated with insulin resistance, this was not observed among the non-CHD subjects. |
Databáze: | OpenAIRE |
Externí odkaz: |