Cognitive and spectral coherence of EEG alterations in resting state in children with chronic TBI
| Autor: | Javier Alducin-Castillo, Marlene Galicia-Alvarado, Oscar Yanez-Suarez, Blanca Flores-Ávalos, Maura J. Ramírez-Flores, Ana Laura Sánchez Quezada |
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| Rok vydání: | 2019 |
| Předmět: |
cognition
medicine.medical_specialty Medicina Electroencephalography Audiology 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Multivariate analysis of variance medicine Coherence (signal processing) 0501 psychology and cognitive sciences EEG Effects of sleep deprivation on cognitive performance Neuropsychological assessment child medicine.diagnostic_test Resting state fMRI business.industry traumatic brain injury 05 social sciences Cognition Psychiatry and Mental health Clinical Psychology Mann–Whitney U test business 030217 neurology & neurosurgery |
| Zdroj: | Universidad Nacional Autónoma de México UNAM Redalyc-UNAM Salud Mental (México) Num.2 Vol.42 |
| ISSN: | 0185-3325 |
| DOI: | 10.17711/sm.0185-3325.2019.012 |
| Popis: | Introduction. TBI is associated with alterations in cortico-subcortical connectivity. However, little attention has been paid to its clinical characteristics and functional connectivity in pediatric patients with chronic TBI. Objective. To evaluate the cognitive performance and spectral coherence of a group of children with TBI in non-acute phase. Method. Cross-sectional study of 15 children with chronic TBI and 17 healthy children. The Neuropsychological Assessment of Children (Evaluacion Neuropsicologica Infantil, ENI) was used and the resting activity of the EEG with eyes-closed was recorded. Offline, two-second epochs of the EEG of each participant were chosen and the spectral coherence was estimated in a range of 1.6 to 30 Hz. The cognitive performance between groups was compared with T-test/Mann-Whitney U Test and MANOVA for the coherence values. Results. The TBI group showed a lower performance ( p ≤ 0.05) in metalinguistic, visuospatial skills, attention, memory, non-verbal flexibility, planning, and organization. Differences ( p ≤ 0.000) were found both inter and intrahemispherically in the spectral coherence between the groups, particularly on F1-F3 (95% CI: 0.543 - 0.557) over the whole frequency range and F3-C3 (95% CI: 0.503 - 0.515) in delta, theta, alpha2, and beta frequencies. Discussion and conclusion. Our findings suggest alterations of hypo and hyper functional connectivity, particularly on the frontal and parietal lobes of both hemispheres, even after several years of a TBI. It is possible that a subtle difference in the degree of connectivity is crucial in the genesis or successful development of attentional, mnesic, executive, and visuospatial processes. |
| Databáze: | OpenAIRE |
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