Bariatric Surgery Improves Atherogenic LDL Profile by Triglyceride Reduction
| Autor: | Giovanna Romanato, Luca Busetto, Sabina Zambon, Paola Fioretto, Giovanni Sartore, Franco Favretti, Giuseppe Sergi, Enzo Manzato, Silvia Zanoni, Raffaella Marin |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Small dense ldl Gastroplasty Gastric banding Endocrinology Diabetes and Metabolism Phospholipid Young Adult chemistry.chemical_compound Weight loss Internal medicine Weight Loss medicine Humans Triglycerides Aged Nutrition and Dietetics Triglyceride business.industry Middle Aged medicine.disease Obesity Obesity Morbid Lipoproteins LDL Treatment Outcome Endocrinology chemistry Female Laparoscopy lipids (amino acids peptides and proteins) Surgery Fatty acid composition medicine.symptom business Lipoprotein |
| Zdroj: | Obesity Surgery. 19:190-195 |
| ISSN: | 1708-0428 0960-8923 |
| Popis: | Small dense low-density lipoprotein (LDL) are atherogenic particles frequently observed in obese patients. Fatty acids modulate LDL. Objective of this study was to determine the relations between plasma phospholipid fatty acid composition and the presence of small dense LDL particles in morbidly obese patients treated with laparoscopic gastric banding (LAGB).Small dense LDL, plasma lipids, lipoproteins, apoproteins, and phospholipid fatty acid composition (a marker of dietary fatty acid intake) were quantified before and 12 months after surgery in four men and 11 women who were morbidly obese and (BMI40 kg/m(2)) eligible for surgery, consecutively treated with LAGB at the Department of Medical and Surgical Sciences of the University of Padova.BMI was 48.3 +/- 4.8 kg/m(2) before and 36.1 +/- 5.5 kg/m(2) after LAGB. Plasma triglycerides and apoprotein E levels significantly decreased, while HDL cholesterol significantly increased after LAGB. A reduction of small dense LDL with an increase of LDL relative flotation (0.34 +/- 0.04 before vs 0.38 +/- 0.03 after LAGB, p0.001) was also observed. These modifications were neither related to weight reduction nor to changes in phospholipid fatty acid composition, but they were associated to triglyceride reduction, which explained 76.7% of the LDL relative flotation variation.Weight loss obtained by LAGB in morbidly obese subjects was accompanied by triglyceride reduction, high-density lipoprotein increase, and an improvement of the atherogenic LDL profile. Triglyceride reduction, but not the extent of weight loss or dietary fatty acid modifications, is the determinant of modifications of LDL physical properties in these patients. |
| Databáze: | OpenAIRE |
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