Genome Sequence Survey Identifies Unique Sequences and Key Virulence Genes with Unusual Rates of Amino Acid Substitution in Bovine Staphylococcus aureus
| Autor: | Lisa L. Herron, Christopher Dwan, Vivek Kapur, J. Ross Fitzgerald, Rajit Chakravarty, James M. Musser, Ernest F. Retzel |
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| Rok vydání: | 2002 |
| Předmět: |
Nonsynonymous substitution
clone (Java method) Staphylococcus aureus Immunology Virulence Molecular Genomics Biology medicine.disease_cause Microbiology Genome medicine Animals Humans Mastitis Bovine Pathogen Gene Genetics Whole genome sequencing Infectious Diseases Amino Acid Substitution Genes Bacterial Cattle Female Parasitology Genome Bacterial |
| Zdroj: | Herron, L L, Chakravarty, R, Dwan, C, Fitzgerald, J R, Musser, J M, Retzel, E & Kapur, V 2002, ' Genome sequence survey identifies unique sequences and key virulence genes with unusual rates of amino Acid substitution in bovine Staphylococcus aureus ', Infection and Immunity, vol. 70, no. 7, pp. 3978-81 . |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.70.7.3978-3981.2002 |
| Popis: | Staphylococcus aureus is a major cause of mastitis in bovine and other ruminant species. We here present the results of a comparative genomic analysis between a bovine mastitis-associated clone, RF122, and the recently sequenced human-associated clones, Mu50 and N315, of Staphylococcus aureus . A shotgun sequence survey of ∼10% of the RF122 genome identified numerous unique sequences and those with elevated rates of nonsynonymous substitution. Taken together, these analyses show that there are notable differences in the genomes of bovine mastitis-associated and human clones of S. aureus and provide a framework for the identification of specific factors associated with host specificity in this major human and animal pathogen. |
| Databáze: | OpenAIRE |
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