Prediction of genetic risk for dyslipidemia
| Autor: | Kimihiko Kato, Kei Satoh, Hidemi Yoshida, Masashi Tanaka, Yukitoshi Aoyagi, Yoshinori Nozawa, Shunichiro Warita, Mitsutoshi Oguri, Hitoshi Matsuo, Kiyoshi Yokoi, Sahoko Ichihara, Akitomo Yasunaga, Norifumi Metoki, Sachiro Watanabe, Yoshiji Yamada, Hyuntae Park |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Apolipoprotein E Candidate gene Genotype Epidemiology Biology Logistic regression Polymorphism Single Nucleotide Cohort Studies Risk Factors Polymorphism (computer science) Hyperlipidemia Genetics medicine Humans Prospective Studies Polymorphism Aged Dyslipidemias Cholesterol HDL Hypertriglyceridemia nutritional and metabolic diseases Cholesterol LDL Middle Aged Prognosis medicine.disease Lipids Lipoprotein Lipase Apolipoproteins Dyslipidemia Female lipids (amino acids peptides and proteins) Biomarkers |
| Zdroj: | Genomics. 90:551-558 |
| ISSN: | 0888-7543 |
| Popis: | The purpose of the present study was to identify genetic variants that confer susceptibility to dyslipidemia. A total of 5213 individuals from two independent populations were examined: Subject panel A comprised 3794 individuals who visited participating hospitals; subject panel B comprised 1419 community-dwelling elderly individuals. The genotypes for 100 polymorphisms of 65 candidate genes were determined. The χ 2 test and multivariable logistic regression analysis revealed that seven polymorphisms of APOA5, APOC3, APOA1, ACAT2, and LPL were significantly associated with hypertriglyceridemia, six polymorphisms of APOA5, LIPC , and CYP3A4 with low HDL-cholesterol, and three polymorphisms of APOE and CCR2 with high LDL-cholesterol in subject panel A. For validation of these associations, the same polymorphisms were examined in subject panel B. Six polymorphisms of APOA5, APOC3, APOA1, and LPL were again significantly associated with hypertriglyceridemia, three polymorphisms of APOA5 with low HDL-cholesterol, and two polymorphisms of APOE with high LDL-cholesterol. Serum triglyceride, HDL-cholesterol, and LDL-cholesterol concentrations differed significantly among genotypes of these corresponding polymorphisms in both subject panels. These results indicate that polymorphisms of APOA5, APOC3, APOA1, and LPL are determinants of hypertriglyceridemia and that those of APOA5 and APOE are determinants of low HDL-cholesterol and high LDL-cholesterol, respectively, in Japanese individuals. |
| Databáze: | OpenAIRE |
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