Role of Genetic Susceptibility in the Development of Bronchopulmonary Dysplasia
| Autor: | Munish Gupta, Ivana Thompson, JoAnn Morey, Yvonne Sheldon, Linda J. Van Marter, Leslie A. Kalish, Abigail B. Winston, Richard B. Parad |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Databases Factual Gestational Age Risk Assessment Cohort Studies 03 medical and health sciences 0302 clinical medicine Pregnancy Cause of Death 030225 pediatrics mental disorders Prevalence Twins Dizygotic medicine Humans Genetic Predisposition to Disease 030212 general & internal medicine Bronchopulmonary Dysplasia Retrospective Studies business.industry Obstetrics Infant Newborn Gestational age Retrospective cohort study Twins Monozygotic Heritability medicine.disease Twin Studies as Topic Twin study Zygosity Survival Rate Bronchopulmonary dysplasia Infant Extremely Premature Pediatrics Perinatology and Child Health Pregnancy Twin Female Monochorionic twins business Boston |
| Zdroj: | The Journal of Pediatrics. 203:234-241.e2 |
| ISSN: | 0022-3476 |
| Popis: | Objective To assess heritable contributions to bronchopulmonary dysplasia (BPD) risk in a twin cohort restricted to gestational age at birth Study design A total of 250 twin pairs (192 dichorionic, 58 monochorionic) born Results χ2 analyses comparing whether neither, 1, or both of monochorionic (23, 19, 16) and dichorionic (88, 56, 48) twin pairs developed BPD revealed no difference. Although there was similarity in BPD outcome within both monochorionic and dichorionic twin pairs by ICC (monochorionic ICC = 0.34, 95% CI [0.08, 0.55]; dichorionic ICC = 0.39, 95% CI [0.25, 0.51]), monochorionic twins were not more likely than dichorionic twins to have the same outcome (P = .70). ACE modeling revealed no contribution of heritability to BPD risk (% A = 0.0%, 95% CI [0.0%, 43.1%]). Validation and zygosity based cohort results were similar. Conclusions Our analysis suggests that heritability is not a major contributor to BPD risk in preterm infants |
| Databáze: | OpenAIRE |
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