Association of the manganese superoxide dismutase gene Ala–9Val polymorphism with clinical phenotypes and tardive dyskinesia in schizophrenic patients
| Autor: | Da Chun Chen, Mei Hong Xiu, Pin Hong Chen, You Lan Zheng, Yu Wang, Hong Liu, Xiang Yang Zhang, Hua Qing Meng, Cui Wang, Thomas R. Kosten, Chong Xi Zhang, Ben Shu Zhang |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Dyskinesia Drug-Induced medicine.medical_specialty Genotype Population Single-nucleotide polymorphism Pharmacology Tardive dyskinesia Polymorphism Single Nucleotide Severity of Illness Index Gastroenterology Asian People Gene Frequency Internal medicine medicine Humans SNP Genetic Predisposition to Disease Allele education Alleles Genetic Association Studies Biological Psychiatry Aged Genetic association Psychiatric Status Rating Scales Analysis of Variance education.field_of_study Positive and Negative Syndrome Scale Superoxide Dismutase business.industry Middle Aged medicine.disease Phenotype Haplotypes Schizophrenia Regression Analysis Female business Antipsychotic Agents |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 34:692-696 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/j.pnpbp.2010.03.026 |
| Popis: | Objective Several recent studies that have investigated the genetic association between the manganese superoxide dismutase ( MnSOD ) gene Ala–9Val single-nucleotide polymorphism (SNP) and tardive dyskinesia (TD) have produced conflicting results. This study was to investigate whether this SNP was associated with clinical phenotypes and antipsychotic-induced tardive dyskinesia (TD) in schizophrenia in a genetically homogeneous Han Chinese inpatient population. Methods Genotyping was performed for the MnSOD gene Ala–9Val SNP in Chinese schizophrenia patients with ( n = 176) and without TD ( n = 346). The severity of TD was assessed using the abnormal involuntary movement scale (AIMS), and psychopathology using the Positive and Negative Syndrome Scale (PANSS). Results The frequencies of genotypes and alleles did not differ significantly between schizophrenic patients with and without TD (both p > 0.05). Also, there was no significant difference in the AIMS total score between the Val/Val and Ala allele carrier groups ( p > 0.05). However, the PANSS negative symptom subscore was significantly higher in patients with Val/Val genotype (21.8 ± 7.3) than those with Ala alleles (20.1 ± 7.7) ( t = 2.32, p = 0.03). Conclusion While the MnSOD gene Ala–9Val polymorphism did not play a major role in the susceptibility to TD in schizophrenic patients, it might be associated with negative symptoms of schizophrenia. |
| Databáze: | OpenAIRE |
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