Cervicofacial actinomycosis: a report of 14 patients observed at the Dermatology Unit of the University of Milan, Italy
| Autor: | Serena Giacalone, Stefano Veraldi, Paolo Bortoluzzi, Gianluca Nazzaro |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Benzathine benzylpenicillin
medicine.medical_specialty medicine.medical_treatment Dermatology Oral cavity Actinomycosis 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Retrospective Studies Debridement Actinomyces spp business.industry Cervicofacial Actinomycosis Retrospective cohort study Amoxicillin Anti-Bacterial Agents Italy chemistry 030220 oncology & carcinogenesis business Actinomycoses medicine.drug |
| Zdroj: | International Journal of Dermatology. 59:1222-1225 |
| ISSN: | 1365-4632 0011-9059 |
| DOI: | 10.1111/ijd.14934 |
| Popis: | Background Actinomycoses are rare chronic infections often caused by Actinomyces spp. Cervicofacial actinomycosis (CFA) is caused by primary lesions in the oral cavity and subsequent fistulae, and suppurative and granulomatous lesions on the skin of the face. Methods We present the results of a retrospective study on 14 patients with CFA, observed in the period 1984-2019 at the Dermatology Unit of the University of Milan. Physical general and dermatologic examinations, instrumental tests, and histopathologic and bacteriologic examinations were carried out in all patients. In three patients, polymerase chain reaction was also carried out. Results Six patients showed poor oral hygiene; eight patients had been subjected to previous surgical operations in the oral cavity. Histopathologic examination was superimposable in all patients. In four patients, bacteriologic examinations were positive for A. israelii. In three patients, polymerase chain reaction was positive for A. israelii. X-rays of the bones of the face showed osteolytic lesions in four patients. All patients were successfully treated with benzathine benzylpenicillin followed by amoxicillin or with amoxicillin in monotherapy. In all patients, surgical drainage and debridement of the oral cavity were carried out. Conclusion CFA is a rare infection caused by primary lesions in the oral cavity and subsequent fistulae, and nodular and ulcerative lesions on the skin of the face. Clinical diagnosis must be confirmed by histopathologic, bacteriologic, and instrumental examinations. Therapy with penicillins is usually very long and must be accompanied by surgical drainage and debridement of the oral cavity. |
| Databáze: | OpenAIRE |
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