Amphiphilic anti-SARS-CoV-2 drug remdesivir incorporates into the lipid bilayer and nerve terminal membranes influencing excitatory and inhibitory neurotransmission

Autor:	Natalia Krisanova, Natalia Pozdnyakova, Artem Pastukhov, Marina Dudarenko, Oleg Shatursky, Olena Gnatyuk, Uliana Afonina, Kyrylo Pyrshev, Galina Dovbeshko, Semen Yesylevskyy, Tatiana Borisova
Rok vydání:	2022
Předmět:	Alanine SARS-CoV-2 Lipid Bilayers Biophysics Animals Cell Biology Rats Wistar Biochemistry Synaptic Transmission Adenosine Monophosphate gamma-Aminobutyric Acid Rats COVID-19 Drug Treatment
Zdroj:	Biochimica et biophysica acta. Biomembranes. 1864(8)
ISSN:	1879-2642
Popis:	Remdesivir is a novel antiviral drug, which is active against the SARS-CoV-2 virus. Remdesivir is known to accumulate in the brain but it is not clear whether it influences the neurotransmission. Here we report diverse and pronounced effects of remdesivir on transportation and release of excitatory and inhibitory neurotransmitters in rat cortex nerve terminals (synaptosomes) in vitro. Direct incorporation of remdesivir molecules into the cellular membranes was shown by FTIR spectroscopy, planar phospholipid bilayer membranes and computational techniques. Remdesivir decreases depolarization-induced exocytotic release of L-[
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61d48adbc33d8228529e964d16c28d1 https://pubmed.ncbi.nlm.nih.gov/35461828 Zobrazit plný text záznamu Full Text from ScienceDirect