Number and distribution of melanocytic nevi in individuals with a history of childhood leukemia
| Autor: | Alberto Reseghetti, Tullio Cainelli, Luigi Naldi, Donatella Fraschini, Agrippino Reciputo, Giuseppe Masera, Eugenio Rossi, Lorenzo Imberti, Luigia Adamoli, Adele Corbetta |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Childhood leukemia Adolescent Acute lymphocytic leukemia medicine Nevus Humans Risk factor skin and connective tissue diseases Child Body surface area Nevus Pigmented integumentary system business.industry Melanoma Infant Melanocytic nevus Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Dermatology Numero sign Phenotype Oncology Leukemia Myeloid Child Preschool Acute Disease Female business |
| Zdroj: | Cancer. 77(7) |
| ISSN: | 0008-543X |
| Popis: | BACKGROUND An increased number of melanocytic nevi at the termination of chemotherapy has been documented in children with hematologic malignancies. The persistence of the increased number of nevi over time and the relationship with personal (e.g., phenotype) and disease related variables remain to be explored. METHODS One hundred Italian patients diagnosed as having acute lymphatic or myeloid leukemia, after 1975, were recruited and compared with a group of 100 control individuals drawn from friends of the enrolled patients. Information regarding lifetime sun exposure, phenotypic characteristics, and number of nevi was collected by experienced dermatologists. Counts of nevi were expressed both as totals and as counts per unit of body surface area (“density”). Multiple linear regression analysis was employed to control for potentially confounding factors when comparing patients and controls. RESULTS The patients and controls were fairly comparable in terms of constitutional characteristics, but the patients had a significantly higher number and density of nevi; ce 2 mm or larger in diameter. In addition, patients had a greater number of large nevi (;ce6 mm in greatest dimension), and of nevi in unusual areas, such as the palms and soles. Differences in nevus density between patients and controls were notably maintained in the older age group (> 12 years). None of the disease-related factors analyzed (e.g., treatment protocol and radiotherapy), appeared to be significantly correlated with nevus density. CONCLUSIONS Patients with a history of childhood leukemia have a sustained increase in their nevus density. A fairly convincing body of evidence indicates that a large number of melanocytic nevi is the strongest risk factor for melanoma. Therefore, the utility of periodic skin examination of these individuals should be considered. Cancer 1996;77:1402-8. |
| Databáze: | OpenAIRE |
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