Epileptic seizure activity in the acute phase following cortical impact trauma in rat
| Autor: | Urban Ungerstedt, Hans Carlson, Lars Hillered, Elisabeth Ronne-Engström, Roland Flink, Pelle Nilsson |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Microdialysis Taurine Traumatic brain injury Central nervous system Ischemia Rats Sprague-Dawley chemistry.chemical_compound Epilepsy Seizures medicine Animals Amino Acids Molecular Biology Brain Concussion Brain Chemistry Cerebral Cortex business.industry General Neuroscience Glutamate receptor Electroencephalography medicine.disease Rats medicine.anatomical_structure chemistry Anesthesia Neurology (clinical) Epileptic seizure medicine.symptom Extracellular Space business Developmental Biology |
| Zdroj: | Brain Research. 637:227-232 |
| ISSN: | 0006-8993 |
| Popis: | The aim of this investigation was to determine the incidence of seizure activity in the acute phase following traumatic brain injury. Compression contusion trauma was produced in the right parietal cortex in 19 artificially ventilated rats. Electroencephalographic recordings were carried out in 17 of the animals for 2 h following the impact. The extracellular levels of neuroactive amino acids were simultaneously monitored in 9 of the experiments using microdialysis. In 14 of the 17 animals a generalized seizure activity with an average duration of 59 s (range 30–101 s) was recorded. The mean time lag between trauma and seizure onset was 67 s (range 26–90 s). The seizure activity was consistently followed by post-ictal depression. The trauma was accompanied by a transient increase of aspartate, taurine, glutamate and glycine, in decreasing rank order. The seizure activity occured when the levels of these neuroactive amino acids were elevated. It is concluded that the high incidence of seizure activity observed may be an important factor contributing to secondary ischemia after traumatic brain injury. Aspartate and glutamate, potentiated by glycine, may play a role in post-traumatic seizure activity. |
| Databáze: | OpenAIRE |
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