Cerebral cortex structure in prodromal Huntington disease
| Autor: | Peggy Nopoulos, Anne Rosser, Stefan Klöppel, Roger Alistair Barker, Stacie Vik, Douglas Langbehn, Thomas Warner, Lynn Raymond, Hans Johnson, Georg Bernhard Landwehrmeyer, Jane Paulsen, Vincent Magnotta |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Surface area Disease Gene mutation Article Cortical thickness lcsh:RC321-571 Neuroimaging Cortex (anatomy) Internal medicine medicine Humans Longitudinal Studies lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Temporal cortex medicine.diagnostic_test Cerebrum Magnetic resonance imaging Middle Aged Huntington disease Cerebral cortex Magnetic Resonance Imaging medicine.anatomical_structure Early Diagnosis Neurology Cardiology Female Psychology MRI |
| Zdroj: | Neurobiology of Disease, Vol 40, Iss 3, Pp 544-554 (2010) |
| Popis: | Neuroimaging studies of subjects who are gene-expanded for Huntington Disease, but not yet diagnosed (termed prodromal HD), report that the cortex is "spared," despite the decrement in striatal and cerebral white-matter volume. Measurement of whole-cortex volume can mask more subtle, but potentially clinically relevant regional changes in volume, thinning, or surface area. The current study addressed this limitation by evaluating cortical morphology of 523 prodromal HD subjects. Participants included 693 individuals enrolled in the PREDICT-HD protocol. Of these participants, 523 carried the HD gene mutation (prodromal HD group); the remaining 170 were non gene-expanded and served as the comparison group. Based on age and CAG repeat length, gene-expanded subjects were categorized as "Far from onset," "Midway to onset," "Near onset," and "already diagnosed." MRI scans were processed using FreeSurfer. Cortical volume, thickness, and surface area were not significantly different between the Far from onset group and controls. However, beginning in the Midway to onset group, the cortex showed significant volume decrement, affecting most the posterior and superior cerebral regions. This pattern progressed when evaluating the groups further into the disease process. Areas that remained mostly unaffected included ventral and medial regions of the frontal and temporal cortex. Morphologic changes were mostly in thinning as surface area did not substantially change in most regions. Early in the course of HD, the cortex shows changes that are manifest as cortical thinning and are most robust in the posterior and superior regions of the cerebrum. |
| Databáze: | OpenAIRE |
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