Carthami flos: a review of its ethnopharmacology, pharmacology and clinical applications
| Autor: | Dandan Guo, Yanhua Tu, Yingru Xue, Lian-Na Sun, Meili Guo |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pharmacology
Myocardial ischemia Traditional medicine biology business.industry Chronic pulmonary heart disease lcsh:RS1-441 Flos Traditional Chinese medicine Disease Clinical applications medicine.disease biology.organism_classification lcsh:Pharmacy and materia medica Angina Carthami flos Pharmacology Toxicology and Pharmaceutics(all) Diabetes mellitus Antithrombotic medicine General Pharmacology Toxicology and Pharmaceutics Side effects business |
| Zdroj: | Revista Brasileira de Farmacognosia, Volume: 25, Issue: 5, Pages: 553-566, Published: OCT 2015 Revista Brasileira de Farmacognosia, Vol 25, Iss 5, Pp 553-566 Revista Brasileira de Farmacognosia v.25 n.5 2015 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Revista Brasileira de Farmacognosia, Vol 25, Iss 5, Pp 553-566 (2015) |
| ISSN: | 0102-695X |
| DOI: | 10.1016/j.bjp.2015.06.001 |
| Popis: | Carthami flos, the dried floret of Carthamus tinctorius L., Asteraceae (safflower), has been widely used in traditional Chinese medicine to treat a broad range of ailments, such as coronary heart disease, angina pectoris, gynecologic disease, stroke, and hypertension. However, although several studies on Carthami flos have been done consecutively, the results are usually scattered across various documents. This review aims to provide up-to-date information on the traditional uses, pharmacology, clinical applications, and toxicology of Carthami flos in China and thereby to provide a basis for further investigation of its use to treat dissimilar diseases. Various ethnomedical uses of Carthami flos have been documented in many ancient Chinese books. Crude extracts and isolated compounds from Carthami flos show a broad range of pharmacological properties, such as protective effects on brain tissue, on osteoblasts, and in myocardial ischemia, as well as anti-inflammatory, antithrombotic, antitumor, and antidiabetic activities. To date, safflower and safflor yellow injections have been used to treat coronary heart disease, chronic pulmonary heart disease, cerebrovascular diseases, orthopedic diseases, and diabetes mellitus. Regarding the toxicology of Carthami flos, among the side effects that have been observed are allergic reaction, spermatogenetic failure, fatty liver, and nephrotoxicity. Keywords: Carthami flos, Pharmacology, Clinical applications, Side effects |
| Databáze: | OpenAIRE |
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