Association of serum lipid components and obesity with genetic ancestry in an admixed population of elderly women
| Autor: | Alause S. Pires, Clayton Franco Moraes, Rodrigo G. Vieira, Tulio C. Lins, Otávio de Toledo Nóbrega, Roberta Silva Paula, Rinaldo Wellerson Pereira, Lucy Gomes Vianna |
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| Předmět: |
obesity
lcsh:QH426-470 Genetic genealogy Population Genetic admixture postmenopausal women Biology Bioinformatics Mulheres idosas Hyperlipidemia Genetics medicine education Molecular Biology education.field_of_study medicine.diagnostic_test Mulheres - nutrição Hypertriglyceridemia dyslipidemia Obesidade em mulheres Genética de populações medicine.disease Obesity Mulheres - saúde e higiene genetic ancestry lcsh:Genetics lipid profile Human and Medical Genetics Lipid profile Body mass index Demography Research Article |
| Zdroj: | ResearcherID Genetics and Molecular Biology Repositório Institucional da UnB Universidade de Brasília (UnB) instacron:UNB Genetics and Molecular Biology, Volume: 35, Issue: 3, Pages: 575-582, Published: 13 JUL 2012 Genetics and Molecular Biology v.35 n.3 2012 Sociedade Brasileira de Genética (SBG) instacron:SBG Genetics and Molecular Biology, Vol 35, Iss 3, Pp 575-582 (2012) |
| Popis: | The prevalence of metabolic disorders varies among ethnic populations and these disorders represent a critical health care issue for elderly women. This study investigated the correlation between genetic ancestry and body composition, metabolic traits and clinical status in a sample of elderly women. Clinical, nutritional and anthropometric data were collected from 176 volunteers. Genetic ancestry was estimated using 23 ancestry-informative markers. Pearsons correlation test was used to examine the relationship between continuous variables and an independent samples t-test was used to compare the means of continuous traits within categorical variables. Overall ancestry was a combination of European (57.49%), Native American (25.78%) and African (16.73%). Significant correlations were found for European ancestry with body mass index (r = 0.165; p = 0.037) and obesity (mean difference (MD) = 5.3%; p = 0.042). African ancestry showed a significant correlation with LDL (r = 0.159, p = 0.035), VLDL (r = -0.185; p = 0.014), hypertriglyceridemia (MD = 6.4%; p = 0.003) and hyperlipidemia (MD = 4.8%; p = 0.026). Amerindian ancestry showed a significant correlation with triglyceride levels (r = 0.150; p = 0.047) and hypertriglyceridemia (MD = 4.5%; p = 0.039). These findings suggest that genetic admixture may influence the etiology of lipid metabolism-related diseases and obesity in elderly women. |
| Databáze: | OpenAIRE |
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