Corneal endothelial cell injury induced by mitomycin-C in photorefractive keratectomy: Nonrandomized controlled trial
| Autor: | Mohammad Rahnavardi, Nariman Nassiri, Laleh Rahmani, Nader Nassiri, Saman Farahangiz |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Alkylating Agents medicine.medical_specialty Corneal endothelium Visual acuity Adolescent genetic structures Endothelium Cell Survival Mitomycin medicine.medical_treatment Visual Acuity Cell Count Refraction Ocular Photorefractive Keratectomy Corneal Diseases Cornea Ophthalmology Myopia medicine Humans Prospective Studies Eye surgery business.industry Endothelium Corneal digestive oral and skin physiology Mitomycin C Middle Aged Ablation eye diseases Sensory Systems Photorefractive keratectomy Surgery medicine.anatomical_structure Female Lasers Excimer sense organs medicine.symptom business |
| Zdroj: | Journal of Cataract and Refractive Surgery. 34:902-908 |
| ISSN: | 0886-3350 |
| DOI: | 10.1016/j.jcrs.2008.03.007 |
| Popis: | Purpose To evaluate the effect of intraoperative use of mitomycin-C (MMC) on the corneal endothelium during excimer laser photorefractive keratectomy (PRK). Setting Vanak Eye Surgery Center, Tehran, Iran. Methods This nonrandomized trial comprised 81 patients (162 eyes) with bilateral low to moderate myopia and adequate corneal thickness to allow PRK (estimated postoperative residual stromal thickness >350 μm without considering epithelial thickness). The indication for intraoperative application of MMC 0.02% (0.2 mg/mL) was an ablation depth of 75 μm or more. Patients were divided into 3 groups: bilateral (both eyes treated with MMC), unilateral (only 1 eye treated with MMC), and untreated (no eye treated with MMC). Visual acuity, refraction, endothelial cell density (ECD), and corneal thickness were measured preoperatively as well as 1 week and 1, 3, and 6 months postoperatively. Results Overall, 76 eyes were treated with MMC. Eyes treated with MMC and untreated eyes were comparable in postoperative visual acuity and refraction. Preoperative to postoperative changes in ECD were statistically significantly greater in the treated eyes (−14.8%) than in untreated eyes (−5.1%) 6 months after PRK ( P .001). Longer MMC contact time ( P P = .04) were the only factors independently associated with greater endothelial cell loss. Conclusions The prophylactic use of diluted intraoperative MMC 0.02% solution caused corneal endothelial cell loss. The rate of cell loss was correlated with the duration of MMC exposure. |
| Databáze: | OpenAIRE |
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