DNA Restriction Polymorphism of α-fetoprotein Gene after Digestion by Mspl Endonuclease
| Autor: | Cécile Rahuel, José M. Sala-Trepat, M. Frain, S. Lavareda de Souza, Gérard Lucotte |
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| Rok vydání: | 1985 |
| Předmět: |
Genetics
Polymorphism Genetic biology Nucleic Acid Hybridization DNA Restriction Enzymes Molecular biology Restriction fragment chemistry.chemical_compound Terminal restriction fragment length polymorphism Restriction enzyme Endonuclease chemistry Complementary DNA biology.protein Humans alpha-Fetoproteins Restriction fragment length polymorphism Gene Genetics (clinical) DNA |
| Zdroj: | Human Heredity. 35:394-398 |
| ISSN: | 1423-0062 0001-5652 |
| Popis: | Hybridization of alpha-fetoprotein clones cDNA with human DNAs digested by seven restriction endonucleases reveals one polymorphism. This polymorphism, detected after restriction by MspI, is at low frequency (f = 0.02) and is validated by family analysis. It corresponds to an intronic sequence, for a methylated site external to the probes utilized. |
| Databáze: | OpenAIRE |
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