In Older Men, Lower Plasma 25-Hydroxyvitamin D Is Associated with Reduced Incidence of Prostate, but Not Colorectal or Lung Cancer
| Autor: | Bu B. Yeap, Kieran McCaul, Jonathan Golledge, Leon Flicker, Yuen Y. E. Wong, Graeme J. Hankey, Zoë Hyde |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Oncology medicine.medical_specialty Lung Neoplasms Epidemiology Colorectal cancer lcsh:Medicine 03 medical and health sciences Prostate cancer 0302 clinical medicine Risk Factors Prostate Internal medicine Medicine and Health Sciences medicine Vitamin D and neurology Humans 030212 general & internal medicine Vitamin D lcsh:Science Lung cancer Prospective cohort study Aged Aged 80 and over Multidisciplinary business.industry Incidence (epidemiology) lcsh:R Prostatic Neoplasms medicine.disease 3. Good health Biomarker Epidemiology medicine.anatomical_structure 030220 oncology & carcinogenesis lcsh:Q Colorectal Neoplasms business Cancer Epidemiology Research Article Blood sampling |
| Zdroj: | PLoS ONE, Vol 9, Iss 6, p e99954 (2014) ResearcherID PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0099954 |
| Popis: | Context and objective Prostate, colorectal and lung cancers are common in men. In this study, we aimed to determine whether vitamin D status is associated with the incidence of these cancers in older men. Design Prospective cohort study. Setting and participants 4208 older men aged 70–88 years in Perth, Western Australia Main outcome measures Plasma 25-hydroxyvitamin D [25(OH)D] concentration was measured by immunoassay. New diagnoses of prostate, colorectal and lung cancers were determined via electronic record linkage. Results During a mean follow-up of 6.7±1.8 years, there were 315, 117 and 101 new diagnoses of prostate, colorectal and lung cancer. In multivariate competing risks proportional hazards models, every 10 nmol/l decrease in 25(OH)D concentration was associated with a 4% reduction in prostate cancer incidence (sub-hazard ratio [SHR] 0.96, 95% confidence interval [CI] 0.92–1.00). Every halving of 25(OH)D concentration was associated with a 21% reduction in incident prostate cancer in multivariate analysis (SHR 0.79, 95% CI 0.63–0.99). Following exclusion of prostate cancer cases diagnosed within 3 years of blood sampling, low 25(OH)D 75 nmol/l was associated with higher incidence, when compared to the reference range 50–75 nmol/l, respectively (p = 0.027). Significant associations were also observed when 25(OH)D was modeled as a quantitative variable. No associations were observed between plasma 25(OH)D concentration with incidence of colorectal or lung cancer. Conclusion Lower levels of vitamin D may reduce prostate cancer risk in older men. By contrast, levels of vitamin D did not predict incidence of colorectal or lung cancers. Further studies are needed to determine whether a causal relationship exists between vitamin D and prostate cancer in ageing men. |
| Databáze: | OpenAIRE |
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