Contusion Spinal Cord Injury Rat Model
| Autor: | Chiu Chuan-Wen, Shie-Liang Hsieh, Henrich Cheng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
business.industry Strategy and Management Mechanical Engineering Rat model Metals and Alloys medicine.disease Spinal cord Industrial and Manufacturing Engineering Pathophysiology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Animal model medicine.anatomical_structure Anesthesia Tissue damage medicine Paralysis Methods Article medicine.symptom Severe disability business Spinal cord injury 030217 neurology & neurosurgery |
| Zdroj: | Bio Protoc |
| Popis: | Spinal cord injury (SCI) can lead to severe disability, paralysis, neurological deficits and even death. In humans, most spinal cord injuries are caused by transient compression or contusion of the spinal cord associated with motor vehicle accidents. Animal models of contusion mimic the typical SCI's found in humans and these models are key to the discovery of progressive secondary tissue damage, demyelination, and apoptosis as well as pathophysiological mechanisms post SCI. Here we describe a method for the establishment of an efficient and reproducible contusion model of SCI in adult rat. |
| Databáze: | OpenAIRE |
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