Quantitative ischemia detection during cardiac magnetic resonance stress testing by use of FastHARP

Autor: John Andrew Derbyshire, Ernesto Castillo, Smita Sampath, Raymond C. Boston, Jerry L. Prince, Dara L. Kraitchman, David A. Bluemke, Bernhard Gerber, Nael F. Osman
Přispěvatelé: UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - MD/MINT - Département de médecine interne
Jazyk: angličtina
Rok vydání: 2003
Předmět:
medicine.medical_specialty
Time Factors
Stress testing
Coronary Disease - complications
diagnosis
physiopathology
Ischemia
Myocardial Ischemia
Magnetic Resonance Imaging
Cine
Coronary Disease
Myocardial Reperfusion
Harmonic phase
Electrocardiography
Dogs
Myocardial Ischemia - diagnosis
etiology
physiopathology
Heart Rate
Predictive Value of Tests
Physiology (medical)
Coronary Circulation
medicine
Animals
Magnetic Resonance Imaging - methods
cardiovascular diseases
Systole
medicine.diagnostic_test
Fourier Analysis
Vascular disease
business.industry
Myocardium
Magnetic resonance imaging
Myocardium - pathology
medicine.disease
Magnetic Resonance Imaging
Myocardial Contraction
Exercise Test - adverse effects
Microspheres
Disease Models
Animal
Coronary occlusion
Disease Progression
Exercise Test
Radiology
Cardiology and Cardiovascular Medicine
business
Cardiac magnetic resonance
Zdroj: Circulation, Vol. 107, no.15, p. 2025-30 (2003)
Circulation, Vol. 107, no. 15, p. 2025-30 (2003)
Popis: Background— Because ECG alterations caused by ischemia cannot be reliably detected in the high-field MRI environment, detection of wall motion abnormalities is often used to ensure patient safety during stress testing. However, an experienced observer is needed to detect these abnormalities. In this study, we investigate the use of fast harmonic phase (FastHARP) MRI for the quantitative, operator-independent detection of the onset of ischemia during acute coronary occlusion. Methods and Results— Eight mongrel dogs underwent an acute 2-minute closed-chest coronary artery occlusion while continuous FastHARP images were acquired. Full regional wall strain was determined every other heartbeat in a single short-axis imaging slice. After 5 minutes of reperfusion, a second 2-minute ischemic episode was induced during the acquisition of conventional cine wall-motion images. The time at which ECG alterations were observed during the first ischemic period was recorded. The time from occlusion to the detection of ischemia, based on a consensus of 2 blinded observers, was determined for MRI. No significant ischemia was present in 2 animals. In the remaining animals, the onset of ischemia was detected significantly earlier by FastHARP than by cine MRI (9.5±5 versus 33±14 seconds, P Conclusions— The rapid acquisition and detection of induced ischemia with FastHARP MRI shows promise as a nonsubjective method to diagnose significant coronary lesions during MR stress testing.
Databáze: OpenAIRE
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