Tachykinin upregulation in atopic dermatitis

Autor:	Diana Djurfeldt, Husameldin El-Nour, Klas Nordlind, Aram Rasul, Louise Lönndahl, Solbritt Lonne-Rahm, Mikael Holst, Björn Johansson
Rok vydání:	2019
Předmět:	0301 basic medicine Adult Male Biopsy Neurokinin A Immunology Inflammation Context (language use) Substance P Toxicology Dermatitis Atopic 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Nerve Fibers Downregulation and upregulation Surveys and Questionnaires medicine Immunology and Allergy Humans Receptor Skin Pharmacology integumentary system business.industry General Medicine Atopic dermatitis Middle Aged Receptors Neurokinin-1 medicine.disease Up-Regulation 030104 developmental biology Cross-Sectional Studies chemistry 030220 oncology & carcinogenesis Itching Anxiety Female medicine.symptom business
Zdroj:	Immunopharmacology and immunotoxicology. 41(1)
ISSN:	1532-2513
Popis:	Context: Atopic dermatitis (AD) is a chronic, inflammatory, itching skin disorder, which may worsen due to stress, depression and anxiety. Tachykinins may be involved in inflammation signaling as well as they may have a role in stress, depression and anxiety. Objective: This study aimed to measure the expression of tachykinin markers, in the skin of patients with AD, and the correlation of these tachykinins with clinical and psychodemographic parameters. Materials and methods: Twenty-eight adult patients with AD were investigated regarding tachykinin expression in skin biopsies, using an immunohistochemical technique. The patients were characterized with clinical and psychodemographic parameters. Results: The number of substance P and neurokinin (NK)A positive nerve fibers, as well as NKA positive mononuclear dermal cells, was increased in lesional compared to non-lesional skin. Interestingly, the depression score and the number of dermal NK-1 receptor (R) positive cells in lesional as well as in non-lesional skin showed a correlation. Conclusion: These findings indicate an upregulation of the tachykinergic system in the inflamed skin of AD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60d677a3569b20cb6aca012b71f8ca2 https://pubmed.ncbi.nlm.nih.gov/30773959 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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