Canine transmissible venereal sarcoma: Leukocyte adherence inhibition (LAI) reactivity of various lymphoid tissues of dogs with tumors at different stages of growth
| Autor: | Matthew W. Harding, Tsu-Ju (Thomas) Yang |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Lymphoid Tissue Spleen Stages of growth Dogs Antigen Leukocytes medicine Animals Reactivity (chemistry) Tumor growth Neoplasm Staging Venereal Tumors Veterinary Chemistry Clinical course Leukocyte Adherence Inhibition Test medicine.disease Peripheral blood medicine.anatomical_structure Oncology Immunologic Techniques Female Sarcoma Experimental Sarcoma Neoplasm Transplantation |
| Zdroj: | International Journal of Cancer. 27:349-355 |
| ISSN: | 1097-0215 0020-7136 |
| Popis: | Leukocyte adherence inhibition (LAI) reactivity of various lymphoid tissues of dogs with canine transmissible venereal sarcoma (CTVS) at different stages of growth was determined by the tube LAI test. Tumors were classified at the time of excision into progressor, steady state, and regressor stages of growth. The LAI reactivity to CTVS antigen extract of spleen, draining and non-draining lymph-node cells, and peripheral blood leukocytes of regressors (non-adherence index--NAI of 172.8 +/- 46.8, 148.1 +/- 64.7, 138.7 +/- 47.3, and 172.2 +/- 60.7, respectively) was significantly greater than that of progressors (46.1 +/- 20.0, 38.5 +/- 21.5, 50.2 +/- 30.0, 24,6 +/- 37.2, respectively, p less than 0.001) and normal dogs (47.5 +/- 22.8, 54.6 +/- 24.6, 26.7 +/- 14.0, 50.9 +/- 22.4, respectively, p less than 0.001). In contrast, LAI reactivity of progressor lymphoid tissues to CTVS antigen extract did not differ significantly from that of normal dogs. LAI reactivity of lymphoid tissues from steady state tumor bearers (97.9 +/- 39.2, 80.7 +/- 47.3, 87.1 +/- 40.0, 85.1 +/- 53,9, respectively) was intermediate between and significantly different from LAI reactivities of regressor (p less than 0.05) and progressor (p less than 0.01) lymphoid tissues. Significant LAI reactivity observed in regressors suggests the presence of a functional effector cell mechanism associated with spontaneous regression of CTVS. The three distinct patterns of LAI reactivity observed in tumor-bearing dogs appear to correlate with the clinical course of tumor growth. |
| Databáze: | OpenAIRE |
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