Icariin ameliorates learning and memory impairments through ERK/CaMKIIα/CREB signaling and HPA axis in prenatally stressed female offspring

Autor: Yi wei Chen, Yang Li, Si zhe Xia, Huan huan Deng, Xing xing Zheng, Yan jun Cao, Yi song Yue, Ying chun Li, Jiao He
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Morris water navigation task
Hippocampus
Pituitary-Adrenal System
Rats
Sprague-Dawley
chemistry.chemical_compound
0302 clinical medicine
Corticosterone
Pregnancy
Medicine
Neurogranin
Cyclic AMP Response Element-Binding Protein
biology
CREB
Pyramidal Cells
General Medicine
030220 oncology & carcinogenesis
Prenatal Exposure Delayed Effects
Female
Signal Transduction
medicine.medical_specialty
Hypothalamo-Hypophyseal System
Offspring
MAP Kinase Signaling System
Spatial Learning
Calcium-Calmodulin-Dependent Protein Kinase Kinase
RM1-950
Learning and memory
03 medical and health sciences
Memory
Internal medicine
Memory impairment
Animals
Maze Learning
Pharmacology
Flavonoids
Memory Disorders
business.industry
HPA axis
Prenatal stress
Rats
Icariin
Disease Models
Animal
030104 developmental biology
Endocrinology
chemistry
biology.protein
Therapeutics. Pharmacology
business
Stress
Psychological
Zdroj: Biomedicine & Pharmacotherapy, Vol 117, Iss, Pp-(2019)
ISSN: 0753-3322
Popis: Background Prenatal stress (PS) leads to a wide variety of behavioral and emotional aberration observed in later life, particularly in the impairment of spatial learning and memory in offspring. Icariin (ICA) is a naturally occurring furanocoumarin and exhibits many pharmacological properties, including potent improvement on learning and memory. Purpose We pretend to investigate the improvement of ICA on learning and memory impairment in PS. Methods Female PS offspring rats were used to explore the effects of ICA on learning and memory impairment. After 28 days of ICA (20, 40 and 80 mg/kg/day) treatment, we measured Morris water maze and 8-Arm Maze, the HPA axis and the related pathway in the hippocampus. Results We reported that ICA ameliorated the spatial learning and memory and working memory impairment in the female offspring rats. Correspondingly, ICA prevented adverse changes in the dendritic morphology of CA3 pyramidal neurons in the hippocampus. ICA significantly decreased the serum adrenocorticotropin, corticotropin-releasing hormone and corticosterone levels in offspring rats exposed to PS, associated with increased GR expression. Additionally, ICA treatment significantly increased the neurogranin (Ng) and c-fos protein expression of hippocampus in the offspring rats. Furthermore, the protein of relative content of p-EKR/ERK, p-CaMKIIα/CaMKIIα, p-CREB/CREB were remarkably increased after ICA treatment in the offspring rats. Conclusion Taken together, ICA may be an effective therapeutic for learning and memory dysfunction in female offspring exposed to PS, its neuroprotective effect was mediated in part by normalizing the HPA axis and up-regulating of ERK/CaMKIIα/CREB signaling, Ng and c-fos protein.
Databáze: OpenAIRE
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