Effects of TNF antagonists on sperm characteristics in patients with spondyloarthritis
| Autor: | Gion Caliezi, Frauke Förger, Véronique Cottin, Monika Østensen, Peter M. Villiger, Alfred Senn |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Adolescent Immunology Semen Antibodies Monoclonal Humanized Gastroenterology Receptors Tumor Necrosis Factor General Biochemistry Genetics and Molecular Biology Etanercept Young Adult Rheumatology Internal medicine Spondylarthritis medicine Adalimumab Humans Immunology and Allergy Young adult Spermatogenesis Tumor Necrosis Factor-alpha urogenital system business.industry Antibodies Monoclonal Middle Aged Sperm Infliximab Antirheumatic Agents Immunoglobulin G Sperm Motility business medicine.drug |
| Zdroj: | Annals of the Rheumatic Diseases. 69:1842-1844 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2009.127423 |
| Popis: | Objective To study the influence of tumour necrosis factor (TNF) antagonists on spermatogenesis in a cohort of patients with spondyloarthritis (SpA). Patients and methods Semen samples of 26 patients with SpA were analysed according to WHO 1999 guidelines with and without TNF blocking agents (infliximab, etanercept or adalimumab). Results were compared with semen samples of 102 healthy volunteers. Results Sperm abnormalities were found in 10/11 patients without anti-TNF therapy. The sperm of these 11 patients had significantly poorer motility (p=0.001) and vitality (p=0.001) than found in 15 patients tested during longstanding anti-TNF therapy, but sperm concentration and morphology were similar in the two groups. There was no significant difference of sperm quality between healthy controls and anti-TNF treated patients with SpA. Notably, sperm abnormalities were also found in 102 healthy controls. Conclusion Sperm abnormalities are a common finding in healthy men, they are more pronounced in patients with active SpA. The sperm quality of patients with SpA with inactive disease receiving long-term TNF inhibition is comparable to that in healthy controls. The data support continuation of anti-TNF treatment when fatherhood is planned. |
| Databáze: | OpenAIRE |
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