Stage I juvenile granulosa cell tumors of the ovary: A multicentre analysis from the MITO-9 study
| Autor: | Massimo Candiani, Gabriella Ferrandina, Giovanna Scarfone, Gianluca Taccagni, Chiara Cassani, Luca Bocciolone, Sandro Pignata, Giorgio Candotti, Alice Bergamini, Marco Marinaccio, Giorgia Mangili |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Juvenile Type Granulosa Cell Tumor Ovariectomy medicine.medical_treatment Salpingo-oophorectomy Ovary Disease Cystectomy 03 medical and health sciences 0302 clinical medicine Ovarian cancer Median follow-up Internal medicine medicine Humans Minimally Invasive Surgical Procedures Juvenile Child Granulosa Cell Tumor Neoplasm Staging Retrospective Studies Ovarian Neoplasms 030219 obstetrics & reproductive medicine business.industry Juvenile-type ovarian granulosa cell tumors General Medicine Prognosis medicine.disease Granulosa cell tumors Settore MED/40 - GINECOLOGIA E OSTETRICIA medicine.anatomical_structure Italy Oncology 030220 oncology & carcinogenesis Sex cord stromal tumors Female Surgery business |
| Zdroj: | European Journal of Surgical Oncology. 47:1705-1709 |
| ISSN: | 0748-7983 |
| Popis: | Objective Juvenile type granulosa cell tumor (JGCTs) are extremely rare, mainly diagnosed in young women and pre-pubertal girls at stage I disease. Literature is scanty and guidelines regarding the optimal management are still controversial. The aim of this study is to add on the experience of the MITO group (Multicenter Italian Trials in Ovarian Cancer). Methods Clinicopathological data from patients with stage I JGCTs were retrospectively collected. Descriptive statistics were used to characterize the patient population. Clinicopathological features and treatment variables were evaluated for association with relapse. Results Seventeen patients were identified. Surgical approach was laparoscopic and open for 7 (41%) and 10 (59%) patients, respectively. Fertility sparing surgery (FSS) was performed in 15 patients (88%): unilateral salpingo-oophorectomy (USO) in 11 patients, cystectomy with subsequent USO in 2 patients and cystectomy alone in the remaining 2. Adjuvant chemotherapy was given in 2 cases. After a median follow up time of 80 months, no recurrences were registered. Conclusions Given the available data, minimally invasive surgery is safe in stage I JGCTs. Because of the good prognosis and of the young age of patients, FSS can be chosen in most of the cases. The role of cystectomy deserves further validation. The need of adjuvant chemotherapy in stage I disease is still unclear, even if available data does not seem to support treatment over surveillance. |
| Databáze: | OpenAIRE |
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