Antidepressant treatment facilitates dopamine release and drug seeking behavior in a genetic animal model of depression

Autor:	Yakov Flaumenhaft, Ilana Roth-Deri, Yahav Dikshtein, Gal Yadid, Elad Lax, Lital Abraham, Alexander Friedman
Rok vydání:	2009
Předmět:	Dopamine Microdialysis Nucleus accumbens Pharmacology Euphoriant Nucleus Accumbens Cocaine Dopamine Uptake Inhibitors Dopamine receptor D3 Desipramine medicine Animals Dopamine transporter biology Behavior Animal Depression General Neuroscience Anhedonia Antidepressive Agents Rats Behavior Addictive Disease Models Animal biology.protein Antidepressant Autoradiography medicine.symptom Psychology Neuroscience medicine.drug
Zdroj:	The European journal of neuroscience. 30(3)
ISSN:	1460-9568
Popis:	Anhedonia and lack of motivation are core symptoms of depression. In contrast, hyper-motivation and euphoria characterize intoxicated states. In order to explore the relationship between these two behavioral states we examined cocaine self-administration tasks in an animal model of depression [Flinders Sensitive Line (FSL) rats]. We found that FSL rats exhibit sub-sensitivity in their cocaine-seeking behavior, which was normalized following a chronic treatment with the antidepressant desipramine. However, when the cocaine dosage was increased, FSL rats demonstrated a similar cocaine-seeking behavior to that of controls. In light of dopamine's central role in modulating cocaine reinforcement, we examined dopaminergic neurotransmission in the nucleus accumbens, a brain region implicated in the rewarding and hedonic effects of substances of misuse. FSL rats exhibited low but dose-dependent increases in extracellular levels of dopamine in the nucleus accumbens after acute intravenous cocaine injection. Furthermore, by using the dopamine transporter blocker GBR-12909 we were able to demonstrate that the low extracellular dopamine levels, observed in FSL rats, were a consequence of low dopamine release in the nucleus accumbens, as opposed to the possibility of increased uptake. Treatment of FSL rats with the antidepressant desipramine raised cocaine- and GBR-12909-induced dopamine release to the level of controls. This treatment also resulted in increased cocaine-seeking behavior.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ff49db3b7bd47daf2e423a29dac509 https://pubmed.ncbi.nlm.nih.gov/19614746 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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