Soft tissue recurrent ameloblastomas also show some malignant features: a clinicopathological study of a 15-year database
| Autor: | Tiemei Wang, Shanhui Wen, Fei Chen, Guowen Sun, Zitong Lin, Qingang Hu |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Soft Tissue Neoplasm Time Factors Databases Factual Soft Tissue Neoplasms Odontología Malignancy Atypical hyperplasia Malignant transformation Ameloblastoma Atypia Medicine Humans General Dentistry Pathological Aged Retrospective Studies business.industry Research Soft tissue Middle Aged medicine.disease CIENCIAS MÉDICAS [UNESCO] Ciencias de la salud Otorhinolaryngology UNESCO::CIENCIAS MÉDICAS Surgery Female Oral Surgery Neoplasm Recurrence Local business |
| Zdroj: | Lin, Zitong ; Sun, Guowen ; Wang, Tiemei ; Hu, Qingang ; Chen, Fei ; Wen, Shanhui. Soft tissue recurrent ameloblastomas also show some malignant features: a clinicopathological study of a 15-year database. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2015, Vol. 20, No. 3: 12 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname Medicina Oral, Patología Oral y Cirugía Bucal |
| Popis: | Background To investigate the clinicopathological features of six cases of soft tissue recurrent ameloblastoma and explore the role of increased aggressive biological behavior in the recurrences and treatment of this type of ameloblastomas. Material and Methods In this study, we retrospectively reviewed recurrent ameloblastomas during a 15-year period; six cases were diagnosed as soft tissue recurrent ameloblastoma. The clinical, radiographic, cytological and immunohistochemical records of these six cases were investigated and analyzed. Results All the six soft tissue recurrent ameloblastomas occurred after radical bone resection, and were located in the adjacent soft tissues around the osteotomy regions. In Case 4, the patient developed pulmonary metastasis, extensive skull-base infiltration and cytological malignancy after multiple recurrences and malignant transformation was diagnosed. In the other five cases, although there were no cytological signs are sufficient to justify an ameloblastoma as malignant, some malignant features were observed. In Case 1, the tumor showed moderate atypical hyperplasia and the Ki-67 staining percentage was 40% positive, which are strongly suggestive of potential malignance. In Case 5, the patient developed a second soft tissue recurrence in the parapharyngeal region and later died of tumor-related complications. All the remaining three patients showed cytology atypia of varying degrees and high expression of PCNA or Ki-67, which confirmed active cell proliferation. Conclusions Increased aggressiveness is an important factor of soft tissue recurrence. An intraoperative rapid pathological examination and more radical treatment are suggested for these cases. Key words: Ameloblastoma, soft tissue recurrence, aggressive biological behaviour. |
| Databáze: | OpenAIRE |
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