A high-affinity cocaine binding site associated with the brain acid soluble protein 1

Autor:	Maged M. Harraz, Adarsha P. Malla, Evan R. Semenza, Maria Shishikura, Manisha Singh, Yun Hwang, In Guk Kang, Young Jun Song, Adele M. Snowman, Pedro Cortés, Senthilkumar S. Karuppagounder, Ted M. Dawson, Valina L. Dawson, Solomon H. Snyder
Rok vydání:	2022
Předmět:	Dopamine Plasma Membrane Transport Proteins Binding Sites Multidisciplinary Dopamine Receptors Drug Nerve Tissue Proteins Corpus Striatum Rats Cytoskeletal Proteins Mice Cocaine Animals Humans Calmodulin-Binding Proteins Gene Knock-In Techniques Carrier Proteins
Zdroj:	Proceedings of the National Academy of Sciences. 119
ISSN:	1091-6490 0027-8424
DOI:	10.1073/pnas.2200545119
Popis:	Significance Cocaine is a monoamine transport inhibitor. Current models attributing pharmacologic actions of cocaine to inhibiting the activity of the amine transporters alone failed to translate to the clinic. Cocaine inhibition of the dopamine, serotonin, and norepinephrine transporters is relatively weak, suggesting that blockade of the amine transporters alone cannot account for the actions of cocaine, especially at low doses. There is evidence for significantly more potent actions of cocaine, suggesting the existence of a high-affinity receptor(s) for the drug. Identifying and characterizing such receptors will deepen our understanding of cocaine pharmacologic actions and pave the way for therapeutic development. Here we identify a high-affinity cocaine binding site associated with BASP1 that is involved in mediating the drug’s psychotropic actions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fe02ba05d540959d3a5dc2d47bac82 https://doi.org/10.1073/pnas.2200545119 Zobrazit plný text záznamu