Correlation between First-Trimester Maternal Serum Markers, Second-Trimester Uterine Artery Doppler Indices and Pregnancy Outcome
| Autor: | Cem Dane, Murat Kiray, Macit Koldas, Ahmet Çetin, Banu Dane, Murat Erginbas |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Adolescent Pregnancy-associated plasma protein A medicine.drug_class Pregnancy Proteins Sensitivity and Specificity Ultrasonography Prenatal Preeclampsia Young Adult Pre-Eclampsia Predictive Value of Tests Pregnancy Risk Factors medicine.artery medicine Humans Uterine artery Gynecology Obstetrics business.industry Pregnancy Outcome Obstetrics and Gynecology Ultrasonography Doppler Hypertension Pregnancy-Induced medicine.disease Blood proteins Pregnancy Trimester First Uterine Artery Low birth weight Reproductive Medicine Pregnancy Trimester Second Premature Birth Gestation Female Gonadotropin medicine.symptom business Biomarkers |
| Zdroj: | Gynecologic and Obstetric Investigation. 70:126-131 |
| ISSN: | 1423-002X 0378-7346 |
| DOI: | 10.1159/000303260 |
| Popis: | Aims: The aim of this study was to assess the correlation between first trimester maternal serum free beta-human chorionic gonadotropin (fBHCG), pregnancy-associated plasma protein A (PAPPA), second-trimester uterine artery (UA) Doppler measurements and adverse pregnancy outcomes. Methods: Serum levels of PAPPA and fBHCG were determined at the first trimester, and patients underwent bilateral UA Doppler assessments at 20–25 weeks of gestation. A serum PAPPA level 0.52 (mean) or unilateral notch and RI >0.66 (90th percentile). Results: Mean PAPPA level was significantly lower in cases with unilateral or bilateral notches (1.09; 0.79 and 0.80 MoM for 0, 1 and 2 notches, p < 0.001). Fifty-two cases (12.8%) had a low PAPPA level; in this group the incidence of abnormal Doppler was significantly higher (34.6 vs. 18.4%, p = 0.011). In the presence of abnormal Doppler in a case with a low serum PAPPA the risk of pregnancy-induced hypertension (OR = 4.56, p = 0.0067), low birth weight (OR = 6.8, p = 0.0002) and the risk of at least one complication (OR = 7.6, p = 0.00001) were significantly high. Conclusion: Combination of first- and second-trimester findings might improve the efficiency of screening for pregnancy complications. |
| Databáze: | OpenAIRE |
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