Compositional and histological comparison of carbonate apatite fabricated by dissolution-precipitation reaction and Bio-Oss
| Autor: | Naoyuki Fukuda, Takamitsu Mano, Kumiko Kamada, Youji Miyamoto, Go Ohe, Kanji Tsuru, Kunio Ishikawa, Kazuya Akita, Takaharu Kudoh, Kenji Fujisawa |
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| Rok vydání: | 2017 |
| Předmět: |
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Materials science Biomedical Engineering Biophysics Bioengineering Biocompatible Materials 02 engineering and technology Bone and Bones Biomaterials 03 medical and health sciences chemistry.chemical_compound Crystallinity 0302 clinical medicine X-Ray Diffraction Apatites Materials Testing Spectroscopy Fourier Transform Infrared medicine Animals Humans Femur Solubility Particle Size Porosity Calcite Minerals 030206 dentistry 021001 nanoscience & nanotechnology medicine.anatomical_structure Durapatite Orthopedics chemistry Bone Substitutes Microscopy Electron Scanning Carbonate Cortical bone Cattle Particle size Rabbits 0210 nano-technology Nuclear chemistry |
| Zdroj: | Journal of materials science. Materials in medicine. 29(8) |
| ISSN: | 1573-4838 |
| Popis: | Carbonate apatite (CO3Ap) is an inorganic component of bone. This study aimed to compare the composition and tissue response to of CO3Ap (CO3Ap-DP) fabricated by the dissolution-precipitation reaction using calcite as a precursor and Bio-Oss®, which is widely used in orthopedic and dental fields as a synthetic bone substitute. X-ray diffraction and Fourier transform infrared results showed that CO3Ap-DP and Bio-Oss® were both B-type carbonate apatite with low crystallinity. The average sizes of CO3Ap-DP and Bio-Oss® granules were 450 ± 58 and 667 ± 168μ m, respectively, and their carbonate contents were 12.1 ± 0.6 and 5.6 ± 0.1 wt%, respectively. CO3Ap-DP had a larger amount of CO3 than Bio-Oss® but higher crystallinity than Bio-Oss®. When a bone defect made at the femur of rabbits was reconstructed with CO3Ap-DP and Bio-Oss®, CO3Ap-DP granules were partially replaced with bone, whereas Bio-Oss® remained at 8 weeks after implantation. CO3Ap-DP granules elicited a significantly larger amount of new bone formation at the cortical bone portion than Bio-Oss® at 4 weeks after the implantation. The results obtained in the present study demonstrated that CO3Ap-DP and Bio-Oss® showed different behavior even though they were both classified as CO3Ap. The CO3 content in CO3Ap played a more important role than the crystallinity of CO3Ap for replacement to bone and high osteoconductivity. |
| Databáze: | OpenAIRE |
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