Piroxicam Affects Collagen Changes around Experimental Intestinal Anastomoses
| Autor: | P. van Eleren, W. J. B. Mastboom, H.H.M. de Boer, T. Hendriks |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Colon Anastomosis Piroxicam Hydroxyproline chemistry.chemical_compound Surgical anastomosis Ileum Oral administration Weight Loss medicine Animals Experimental surgery Wound Healing business.industry Anastomosis Surgical Rats Inbred Strains Intestinal anastomosis Rats Surgery chemistry Anesthesia Collagen sense organs Wound healing business medicine.drug |
| Zdroj: | European Surgical Research. 21:305-312 |
| ISSN: | 1421-9921 0014-312X |
| Popis: | The effects of piroxicam on postoperative changes of collagen--measured as hydroxyproline--concentrations were measured around intestinal anastomoses in rats. Piroxicam, in a dose of 2 mg/kg/day, significantly reduced the decrease of hydroxyproline concentrations around colonic anastomoses during the first 3 days after the operation but also reduced the increase of hydroxyproline concentrations observed at day 7 around ileal anastomoses in the control group. 10 mg piroxicam/kg/day resulted in a 100% lethal peritonitis after the 5th postoperative day. We suggest that piroxicam affects collagen metabolism by inhibiting granulocyte functions. |
| Databáze: | OpenAIRE |
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