Autologous Bone Marrow Transplantation for Hodgkin's Disease-A Five-Year Single Centre Experience
| Autor: | G. Bass, S. Ager, Trevor Baglin, Robert Marcus, B. Tolliday, J. Z. Wimperis, K. Jestice |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.medical_treatment Drug Resistance Disease Refractory Antineoplastic Combined Chemotherapy Protocols Humans Medicine Life Tables Bone Marrow Transplantation Retrospective Studies Salvage Therapy Hodgkin s Chemotherapy business.industry Marrow transplantation Remission Induction Hematology Prognosis Autologous bone Combined Modality Therapy Hodgkin Disease Survival Analysis Surgery Single centre Treatment Outcome Oncology Female Stem cell business |
| Zdroj: | Leukemia & Lymphoma. 13:263-272 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428199409056290 |
| Popis: | The results from 40 patients who have undergone autologous bone marrow transplantation (ABMT) for relapsed or refractory Hodgkin's disease between March 1988 and September 1992 have been analysed. In contrast to our results in patients with relapsed HD, our results in patients with refractory HD are comparatively poor. Conventional salvage chemotherapy also seems inappropriate in these patients and we therefore believe they should be offered high-dose chemotherapy before their disease becomes refractory to conventionally scheduled regimens. Peripheral blood stem cell (PBSC) transplant now offers an attractive alternative to ABMT and may replace both intensive salvage chemotherapy and ABMT as the optimum treatment for patients who fail to respond to conventional chemotherapy regimens. |
| Databáze: | OpenAIRE |
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