Characterization of an Asymptomatic Cohort of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infected Individuals Outside of Wuhan, China
| Autor: | Jianhua Xiang, Jiang-hua Li, Ting Xie, Jianrong Li, Jin Tong, Yong Cui, Yalan Qin, Elizabeth S. Higgs, Yong He, Jianglin Xiang, Yubo Wang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male medicine.medical_specialty China Adolescent Real-Time Polymerase Chain Reaction Asymptomatic Virus 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Epidemiology Major Article medicine Humans 030212 general & internal medicine Young adult Pandemics Aged Retrospective Studies Aged 80 and over Transmission (medicine) business.industry SARS-CoV-2 COVID-19 Retrospective cohort study Middle Aged AcademicSubjects/MED00290 030104 developmental biology Infectious Diseases Real-time polymerase chain reaction Cohort Female medicine.symptom business |
| Zdroj: | Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America Clinical Infectious Diseases |
| ISSN: | 1537-6591 |
| Popis: | Purpose We aimed to further clarify the epidemiological and clinical characteristics of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Methods We identified close contacts of confirmed coronavirus disease 2019 (COVID-19) cases in northeast Chongqing, China, who were confirmed by real-time reverse transcription polymerase chain reaction-positive (RT-PCR+). We stratified this cohort by normal vs abnormal findings on chest computed tomography (CT) and compared the strata regarding comorbidities, demographics, laboratory findings, viral transmission and other factors. Results Between January 2020 and March 2020, we identified and hospitalized 279 RT-PCR+ contacts of COVID-19 patients. 63 (23%) remained asymptomatic until discharge; 29 had abnormal and 34 had normal chest CT findings. The mean cohort age was 39.3 years, and 87.3% had no comorbidities. Mean time to diagnosis after close contact with a COVID-19 index patient was 16.0 days, and it was 13.4 days and 18.7 days for those with abnormal and normal CT findings, respectively (P < .05). Nine patients (14.3%) transmitted the virus to others; 4 and 5 were in the abnormal and normal CT strata, respectively. The median length of time for nucleic acid to turn negative was 13 days compared with 10.4 days in those with normal chest CT scans (P < .05). Conclusions A portion of asymptomatic individuals were capable of transmitting the virus to others. Given the frequency and potential infectiousness of asymptomatic infections, testing of traced contacts is essential. Studies of the impact of treatment of asymptomatic RT-PCR+ individuals on disease progression and transmission should be undertaken. |
| Databáze: | OpenAIRE |
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