Has the Rate of CD4 Cell Count Decline before Initiation of Antiretroviral Therapy Changed over the Course of the Dutch HIV Epidemic among MSM?
| Autor: | Gras, Luuk, Geskus, Ronald B., Jurriaans, Suzanne, Bakker, Margreet, van Sighem, Ard, Bezemer, Daniela, Fraser, Christophe, Prins, Jan M., Berkhout, Ben, Prins, J. M., Kuijpers, T. W., Scherpbier, H. J., Boer, K., van der Meer, J. T.M., Wit, F. W.M.N., Godfried, M. H., Reiss, P., van der Poll, T., Nellen, F. J.B., Lange, J. M.A., Geerlings, S. E., van Vugt, M., Vrouenraets, S. M.E., Pajkrt, D., Bos, J. C., van der Valk, M., Schreij, G., Lowe, S., Oude Lashof, A., Pronk, M. J.H., Bravenboer, B., van der Ende, M. E., de Vries-Sluijs, T. E.M.S., Schurink, C. A.M., van der Feltz, M., Nouwen, J. L., Gelinck, L. B.S., Verbon, A., Rijnders, B. J.A., van de Ven-de Ruiter, E. D., Slobbe, L., Kauffmann, R. H., Schippers, E. F., Groeneveld, P. H.P., Alleman, M. A., Bouwhuis, J. W., ten Kate, R. W., Soetekouw, R., Kroon, F. P., van den Broek, P. J., van Dissel, J. T., Arend, S. M., van Nieuwkoop, C., de Boer, M. G.J., Jolink, H., den Hollander, J. G., Pogany, K., Bronsveld, W., Kortmann, W., van Twillert, G., van Houte, D. P.F., Polée, M. B., van Vonderen, M. G.A., ten Napel, C. H.H., Kootstra, G. J., Brinkman, K., Blok, W. L., Frissen, P. H.J., Schouten, W. E.M., van den Berk, G. E.L., Juttmann, J. R., van Kasteren, M. E.E., Brouwer, A. E., Mulder, J. W., van Gorp, E. C.M., Smit, P. M., Weijer, S., van Eeden, A., Verhagen, D. W.M., Sprenger, H. G., Doedens, R., Scholvinck, E. H., van Assen, S., Stek, C. J., Hoepelman, I. M., Mudrikova, T., Schneider, M. M.E., Jaspers, C. A.J.J., Ellerbroek, P. M., Peters, E. J.G., Maarschalk-Ellerbroek, L. J., Oosterheert, J. J., Arends, J. E., Wassenberg, M. W.M., van der Hilst, J. C.H., Richter, C., van der Berg, J. P., Gisolf, E. H. |
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| Přispěvatelé: | Internal medicine, Pediatric surgery, Plastic, Reconstructive and Hand Surgery, CCA - Innovative therapy, Pathology, Graduate School, Amsterdam institute for Infection and Immunity, Amsterdam Public Health, Epidemiology and Data Science, Medical Microbiology and Infection Prevention, Infectious diseases, Other departments, Paediatric Infectious Diseases / Rheumatology / Immunology, Other Research, Obstetrics and Gynaecology, Global Health, General Internal Medicine, Center of Experimental and Molecular Medicine, Medische Microbiologie, Interne Geneeskunde, RS: CAPHRI School for Public Health and Primary Care |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
analytical parameters
Epidemiology lcsh:Medicine Human immunodeficiency virus 1 men who have sex with men HIV Infections epidemic Men who have sex with men Efficacy Immunodeficiency Viruses Antiretroviral Therapy Highly Active antiviral therapy Natural Selection Non-U.S. Gov't lcsh:Science Epidemiological Methods Netherlands Multidisciplinary antiretrovirus agent Research Support Non-U.S. Gov't adult disease course article Homosexuality HIV epidemiology Censoring (clinical trials) Medicine Infectious diseases Viral load Research Article Evolutionary Processes Retrovirology and HIV immunopathogenesis Antiretroviral Therapy Viral diseases Research Support Microbiology Viral Evolution virus RNA Acquired immunodeficiency syndrome (AIDS) SDG 3 - Good Health and Well-being male Human immunodeficiency virus infection Virology medicine Journal Article Humans Highly Active human Homosexuality Male Seroconversion Biology seroconversion Evolutionary Biology Surrogate endpoint business.industry human cell lcsh:R HIV CD4 lymphocyte count medicine.disease Antiretroviral therapy major clinical study drug efficacy adolescent Immunology lcsh:Q business Demography |
| Zdroj: | Gras, L, Geskus, R B, Jurriaans, S, Bakker, M, van Sighem, A, Bezemer, D, Fraser, C, Prins, J M, Berkhout, B, Prins, J M, Kuijpers, T W, Scherpbier, H J, Boer, K, van der Meer, J T M, Wit, F W M N, Godfried, M H, Reiss, P, van der Poll, T, Nellen, F J B, Lange, J M A, Geerlings, S E, van Vugt, M, Vrouenraets, S M E, Pajkrt, D, Bos, J C, van der Valk, M, Schreij, G, Lowe, S, Oude Lashof, A, Pronk, M J H, Bravenboer, B, van der Ende, M E, de Vries-Sluijs, T E M S, Schurink, C A M, van der Feltz, M, Nouwen, J L, Gelinck, L B S, Verbon, A, Rijnders, B J A, van de Ven-de Ruiter, E D, Slobbe, L, Kauffmann, R H, Schippers, E F, Groeneveld, P H P, Alleman, M A, Bouwhuis, J W, ten Kate, R W, Soetekouw, R, Kroon, F P, van den Broek, P J, van Dissel, J T, Arend, S M, van Nieuwkoop, C, de Boer, M G J, Jolink, H, den Hollander, J G, Pogany, K, Bronsveld, W, Kortmann, W, van Twillert, G, van Houte, D P F, Polée, M B, van Vonderen, M G A, ten Napel, C H H, Kootstra, G J, Brinkman, K, Blok, W L, Frissen, P H J, Schouten, W E M, van den Berk, G E L, Juttmann, J R, van Kasteren, M E E, Brouwer, A E, Mulder, J W, van Gorp, E C M, Smit, P M, Weijer, S, van Eeden, A, Verhagen, D W M, Sprenger, H G, Doedens, R, Scholvinck, E H, van Assen, S, Stek, C J, Hoepelman, I M, Mudrikova, T, Schneider, M M E, Jaspers, C A J J, Ellerbroek, P M, Peters, E J G, Maarschalk-Ellerbroek, L J, Oosterheert, J J, Arends, J E, Wassenberg, M W M, van der Hilst, J C H, Richter, C, van der Berg, J P & Gisolf, E H 2013, ' Has the Rate of CD4 Cell Count Decline before Initiation of Antiretroviral Therapy Changed over the Course of the Dutch HIV Epidemic among MSM? ', PLoS ONE, vol. 8, no. 5, e64437 . https://doi.org/10.1371/journal.pone.0064437 PLoS ONE, 8(5):e64437. PUBLIC LIBRARY SCIENCE PLoS ONE, 8(5):e64437. Public Library of Science PLoS ONE, Vol 8, Iss 5, p e64437 (2013) PLoS One (print), 8(5). Public Library of Science PLoS ONE, 8(5). Public Library of Science PLOS ONE, 8(5):e64437. Public Library of Science PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0064437 |
| Popis: | Introduction:Studies suggest that the HIV-1 epidemic in the Netherlands may have become more virulent, leading to faster disease progression if untreated. Analysis of CD4 cell count decline before antiretroviral therapy (ART) initiation, a surrogate marker for disease progression, may be hampered by informative censoring as ART initiation is more likely with a steeper CD4 cell count decline.Methods:Development of CD4 cell count from 9 to 48 months after seroconversion was analyzed using a mixed-effects model and 2 models that jointly modeled CD4 cell counts and time to censoring event (start ART, 3, or AIDS) among therapy-naïve MSM HIV-1 seroconverters in the Netherlands. These models make different assumptions about the censoring process.Results:All 3 models estimated lower median CD4 cell counts 9 months after seroconversion in later calendar years (623, 582, and 541 cells/mm3 for 1984-1995 [n = 111], 1996-2002 [n = 139], and 2003-2007 seroconverters [n = 356], respectively, shared-parameter model). Only the 2 joint-models found a trend for a steeper decline of CD4 cell counts with seroconversion in later calendar years (overall p-values 0.002 and 0.06 for the pattern-mixture and the shared-parameter model, respectively). In the shared-parameter model the median decline from 9 to 48 months was 276 cellsmm3 for 1984-1995 seroconverters and 308 cells/mm3 for 2003-2007 seroconverters (difference in slope, p = 0.045).Conclusion:Mixed-effects models underestimate the CD4 cell decline prior to starting ART. Joint-models suggest that CD4 cell count declines more rapidly in patients infected between 2003 and 2007 compared to patients infected before 1996. |
| Databáze: | OpenAIRE |
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