Probing axons using multi‐compartmental diffusion in multiple sclerosis
| Autor: | Junzhong Xu, Enrico Kaden, Fei Ye, Amalie Chen, Giulia Franco, Run Fan, Francesca Bagnato, Seth A. Smith, Hua Li, Daniel C. Alexander, Richard D. Dortch |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Multiple Sclerosis Neurosciences. Biological psychiatry. Neuropsychiatry White matter 03 medical and health sciences 0302 clinical medicine Text mining White matter pathology Nuclear magnetic resonance medicine Humans Axial diffusivity RC346-429 Isotropic resolution Research Articles medicine.diagnostic_test business.industry General Neuroscience Multiple sclerosis Brain Magnetic resonance imaging Middle Aged medicine.disease White Matter Axons 030104 developmental biology medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Female Neurology. Diseases of the nervous system Neurology (clinical) Tissues types business 030217 neurology & neurosurgery RC321-571 Research Article |
| Zdroj: | Annals of Clinical and Translational Neurology Annals of Clinical and Translational Neurology, Vol 6, Iss 9, Pp 1595-1605 (2019) |
| ISSN: | 2328-9503 |
| DOI: | 10.1002/acn3.50836 |
| Popis: | Objects The diffusion‐based spherical mean technique (SMT) provides a novel model to relate multi‐b‐value diffusion magnetic resonance imaging (MRI) data to features of tissue microstructure. We propose the first clinical application of SMT to image the brain of patients with multiple sclerosis (MS) and investigate clinical feasibility and translation. Methods Eighteen MS patients and nine age‐ and sex‐matched healthy controls (HCs) underwent a 3.0 Tesla scan inclusive of clinical sequences and SMT images (isotropic resolution of 2 mm). Axial diffusivity (AD), apparent axonal volume fraction (V ax), and effective neural diffusivity (D ax) parametric maps were fitted. Differences in AD, V ax, and D ax between anatomically matched regions reflecting different tissues types were estimated using generalized linear mixed models for binary outcomes. Results Differences were seen in all SMT‐derived parameters between chronic black holes (cBHs) and T2‐lesions (P ≤ 0.0016), in V ax and AD between T2‐lesions and normal appearing white matter (NAWM) (P |
| Databáze: | OpenAIRE |
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