Canine-Based Strategies for Prevention and Control of Visceral Leishmaniasis in Brazil
| Autor: | Anaiá da Paixão Sevá, Fernando Ferreira, Fredy Galvis Ovallos, Rodrigo Martins Soares, Estela Gallucci Lopes, Eugenia Carrillo, Marcus Amaku, Javier Moreno, Eunice Aparecida Bianchi Galati |
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| Přispěvatelé: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de São Paulo (Brasil) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Veterinary medicine Insecticides Epidemiology lcsh:Medicine Force of infection Culling Disease Vectors 0302 clinical medicine Zoonoses Medicine and Health Sciences Medicine Public and Occupational Health Dog Diseases lcsh:Science Leishmaniasis ZOONOSES POR PROTOZOÁRIOS Mammals Vaccines education.field_of_study Multidisciplinary Mortality rate Vaccination Vaccination and Immunization Infectious Diseases Vertebrates Leishmaniasis Visceral Brazil Research Article Neglected Tropical Diseases medicine.medical_specialty Infectious Disease Control Death Rates Immunology 030231 tropical medicine Population 03 medical and health sciences Dogs Population Metrics Environmental health Parasitic Diseases Vaccination of dogs Animals Humans education Demography Protozoan Infections Population Biology business.industry Public health lcsh:R Organisms Biology and Life Sciences Tropical Diseases medicine.disease Insect Vectors Vector-Borne Diseases 030104 developmental biology Visceral leishmaniasis Amniotes People and Places BRASIL lcsh:Q Preventive Medicine business |
| Zdroj: | PLoS ONE, Vol 11, Iss 7, p e0160058 (2016) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Repisalud Instituto de Salud Carlos III (ISCIII) PLoS ONE |
| Popis: | Correction: Canine-Based Strategies for Prevention and Control of Visceral Leishmaniasis in Brazil. PLoS One. 2016 Sep 8;11(9):e0162854. doi: 10.1371/journal.pone.0162854. PMID: 27606898. Visceral leishmaniasis (VL) is a zoonosis found worldwide. Its incidence has increased in Brazil in recent years, representing a serious public and animal health problem. The strategies applied in Brazil are questionable and are not sufficient to control the disease. Thus, we have compared the efficacy of some of the currently available strategies focused on dogs to prevent and control zoonotic VL in endemic areas by optimizing a mathematical model. The simulations showed that the elimination of seropositive dogs, the use of insecticide-impregnated dog collars, and the vaccination of dogs significantly contribute to reducing the prevalence of infection in both canines and humans. The use of insecticide-impregnated collars presented the highest level of efficacy mainly because it directly affected the force of infection and vector-dog contact. In addition, when used at a coverage rate of 90%, insecticide-impregnated collar was able to decrease the prevalence of seropositive dogs and humans to zero; moreover, because of the easy application and acceptance by the targeted population, these collars may be considered the most feasible for inclusion in public policies among the three simulated measures. Vaccination and euthanasia were efficacious, but the latter method is strongly criticized on ethical grounds, and both methods present difficulties for inclusion in public policies. When we compared the use of euthanasia and vaccination at coverages of 70 and 90%, respectively, the proportion of infected populations were similar. However, on evaluating the implications of both of these methods, particularly the negative aspects of culling dogs and the proportion of animals protected by vaccination, the latter measure appears to be the better option if the total cost is not significantly higher. The comparison of complications and advantages of different control strategies allows us to analyze the optimal measure and offer strategies to veterinary and public health authorities for making decisions to prevent and control zoonotic VL. Hence, improvements in both public and animal health can be achieved in regions with scenarios similar to that considered in the present study; such scenarios are characteristically found in some areas of Brazil and other countries. This work was supported by the National Council for Scientific and Technological Development - Brazil (CNPq, 142612/2010-3), the Coordination for the Improvement of Higher Education Personnel - Brazil (CAPES, Fellowship BEX 9803/11-4), and the São Paulo Research Foundation -Brazil (FAPESP, 2012/01442-4). The funders had role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Sí |
| Databáze: | OpenAIRE |
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