Effect of Platinum-Based Chemoradiotherapy on Cellular Proliferation in Bone Marrow and Spleen, Estimated by (18)F-FLT PET/CT in Patients with Locally Advanced Non-Small Cell Lung Cancer
| Autor: | Andreas Möller, Sarah Everitt, David Ball, Benjamin Solomon, Michael MacManus, Marine Chabrot, Antoine Leimgruber, Rodney J. Hicks |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Lung Neoplasms Neutrophils medicine.medical_treatment Standardized uptake value Bone Marrow Cells Cell Count Gastroenterology chemistry.chemical_compound Fluorodeoxyglucose F18 Internal medicine Carcinoma Non-Small-Cell Lung Medicine Humans Radiology Nuclear Medicine and imaging Lung cancer Etoposide Aged Cell Proliferation Platinum Aged 80 and over Chemotherapy business.industry Cancer Chemoradiotherapy Middle Aged medicine.disease Carboplatin Dideoxynucleosides medicine.anatomical_structure Glucose chemistry Organ Specificity Positron-Emission Tomography Female Bone marrow business Tomography X-Ray Computed Spleen medicine.drug |
| Zdroj: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 55(7) |
| ISSN: | 1535-5667 |
| Popis: | Historically, it has been difficult to monitor the acute impact of anticancer therapies on hematopoietic organs on a whole-body scale. Deeper understanding of the effect of treatments on bone marrow would be of great potential value in the rational design of intensive treatment regimens. 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) is a functional radiotracer used to study cellular proliferation. It is trapped in cells in proportion to thymidine-kinase 1 enzyme expression, which is upregulated during DNA synthesis. This study investigates the potential of (18)F-FLT to monitor acute effects of chemotherapy on cellular proliferation and its recovery in bone marrow, spleen, and liver during treatment with 2 different chemotherapy regimens.Sixty patients with non-small cell lung cancer underwent concurrent radical chemoradiotherapy to 60 Gy in 6 wk with either cisplatin/etoposide (C/E, n = 28) weeks 1 and 5 or weekly carboplatin/paclitaxel (C/P, n = 32) regimens. (18)F-FLT and (18)F-FDG PET with CT were performed at baseline, week 2 (day 9 for (18)F-FLT and day 10 for (18)F-FDG PET), and week 4 (day 23 for (18)F-FLT and day 24 for (18)F-FDG PET). Visual and semiquantitative standardized uptake value (SUV) measurements were performed in bone marrow outside the radiotherapy field, liver, spleen, and small bowel. These were correlated to blood counts and smears in a subset of patients.The C/E group exhibited a drop in bone marrow (18)F-FLT uptake at week 2 (median SUVmax [maximum SUV] decrease to 31%, 8.7-6.0, P0.001), with recovery at week 4, reflecting the absence of chemotherapy between these times. By contrast, the weekly C/P group showed gradually declining bone marrow uptake (P0.05). Spleen uptake in both cohorts decreased at week 2, with intense rebound activity at week 4 (SUVmax week 4 at 58% above baseline: 2.4-3.8, for C/E, respectively, 30% for C/P: 2.7-3.5, P0.001). Liver uptake changed little. (18)F-FLT changes preceded neutrophil count reductions. (18)F-FDG uptake in marrow liver and spleen changed much less than (18)F-FLT.(18)F-FLT imaging may be used to quantify impairment and recovery of bone marrow by specific chemotherapy regimens and may also enable imaging of organ-specific processes such as spleen activation. (18)F-FLT is superior to (18)F-FDG for this purpose. This technology may support novel treatment planning and monitoring approaches in oncology patients. |
| Databáze: | OpenAIRE |
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