Preparation and Evaluation of Berberine Alginate Beads for Stomach-Specific Delivery
Autor: | Huixia Lv, Hui Pang, Yong-Shun Sun, Were L L Munyendo, Zhen-Hai Zhang, Sheng-Liang Zhu |
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Rok vydání: | 2011 |
Předmět: |
Male
Time Factors Calcium alginate Berberine Alginates Pharmaceutical Science chemistry.chemical_element Bead Calcium Article Analytical Chemistry Suspension (chemistry) lcsh:QD241-441 Rats Sprague-Dawley chemistry.chemical_compound Drug Delivery Systems lcsh:Organic chemistry In vivo Drug Discovery otorhinolaryngologic diseases medicine Gastric mucosa Animals Particle Size Physical and Theoretical Chemistry octodecanol gastric residence Chromatography Stomach Organic Chemistry berberine calcium alginate beads buoyancy Microspheres Rats medicine.anatomical_structure Solubility chemistry Organ Specificity Chemistry (miscellaneous) visual_art visual_art.visual_art_medium Regression Analysis Molecular Medicine Gels |
Zdroj: | Molecules; Volume 16; Issue 12; Pages: 10347-10356 Molecules Molecules, Vol 16, Iss 12, Pp 10347-10356 (2011) |
ISSN: | 1420-3049 |
Popis: | The purpose of this research was to prepare floating calcium alginate beads of berberine for targeting the gastric mucosa and prolonging their gastric residence time. The floating beads were prepared by suspending octodecanol and berberine in sodium alginate (SA) solution. The suspension was then dripped into a solution of calcium chloride. The hydrophobic and low-density octodecanol enhanced the sustained-release properties and floating ability of the beads. The bead formulation was optimized for different weight ratios of octodecanol and SA and evaluated in terms of diameter, floating ability and drug loading, entrapment and release. In vitro release studies showed that the floating and sustained release time were effectively increased in gastric media by addition of octodecanol. In vivo studies with rats showed that a significant increase in gastric residence time of beads had been achieved. |
Databáze: | OpenAIRE |
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