PSV-20 Effects of fortified yeast cell wall extract on growth and health of newly weaned pigs under chronic dietary challenges of aflatoxin and deoxynivalenol
| Autor: | Sung Woo Kim, Alexandros Yiannikouris, Debora Muratori Holanda |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | J Anim Sci |
| ISSN: | 1525-3163 0021-8812 |
| Popis: | Pigs are highly susceptible to both aflatoxin and deoxynivalenol. The study aim at investigating the effects of a fortified yeast cell wall extract (YCW-DTX; Mycosorb D+, Alltech, Lexington, KY) on growth and health of newly weaned pigs under chronic dietary challenges of aflatoxin and deoxynivalenol. Forty-eight newly weaned pigs (21 d old) were individually housed and allotted to 4 dietary treatments in a randomized complete block design (sex; initial BW) with 2 factors for 35 d based on 3 phases. Two factors were mycotoxins (deoxynivalenol: 0 or 2 mg/kg during all phases and aflatoxin: 0 or 0.2 mg/kg during phase 3) and YCW-DTX (0 or 0.2%). On d 35, all pigs were euthanized to collect mucosal tissues from the jejunum to measure pro-inflammatory cytokines (TNF-a and IL-8) and oxidative damage markers (malondialdehydes and protein carbonyls). Data were analyzed using MIXED procedure of SAS. Mycotoxins reduced (P < 0.05) ADFI and ADG during the entire period whereas YCW-DTX did not affect growth performance of pigs. Mycotoxins reduced (P < 0.05) serum albumin, creatinine, ALT, and total protein concentrations whereas YCW-DTX increased (P < 0.05) glucose, decreased (P < 0.05) CPK, and tended to decrease AST (P = 0.051) and BUN/creatinine (P = 0.087) in serum. Neither mycotoxins nor YCW-DTX affected pro-inflammatory cytokines and oxidative damage markers in jejunal mucosal tissues. In conclusion, mycotoxins impaired growth performance and hepatic function of newly weaned pigs. The commercial additive partly improved hepatic function and maintained growth performance. |
| Databáze: | OpenAIRE |
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