Smaller pituitary volume in adult patients with obsessive-compulsive disorder
| Autor: | Sinan Ozler, Murad Atmaca, Mustafa Koc, Semih Sec, Bilge Kara, Hanefi Yildirim |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System Obsessive-Compulsive Disorder medicine.medical_specialty Pituitary gland Pituitary-Adrenal System behavioral disciplines and activities Atrophy Obsessive compulsive Internal medicine mental disorders Image Processing Computer-Assisted medicine Humans medicine.diagnostic_test business.industry General Neuroscience Age Factors Magnetic resonance imaging General Medicine medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Endocrinology medicine.anatomical_structure Neurology Pituitary Gland Coronal plane Female Neurology (clinical) Abnormality Psychology Nuclear medicine business Anxiety disorder Endocrine gland |
| Zdroj: | Psychiatry and Clinical Neurosciences. 63:516-520 |
| ISSN: | 1440-1819 1323-1316 |
| DOI: | 10.1111/j.1440-1819.2009.01981.x |
| Popis: | Aims: Another structure in the obsessive–compulsive disorder (OCD) circuit may be the pituitary gland because of the fact that limbic–hypothalamic–pituitary–adrenal (LHPA) axis abnormality has been reported in patients with OCD. There has been only one prior study, however, concerning pituitary volumetry, in which the sample was a pediatric group. The purpose of the present study was therefore to investigate this in an adult OCD patient group using magnetic resonance imaging (MRI). Methods: Pituitary volume was measured in 23 OCD patients and the same number of healthy control subjects. Volumetric measurements were made on T1-weighted coronal MRI, with 2.40-mm-thick slices, at 1.5 T, and were done blindly. Results: A statistically significantly smaller pituitary volume was found in OCD patients compared to healthy controls (age and intracranial volume as covariates). With regard to gender and diagnosis, there was a significant difference in pituitary gland volume (F = 4.18, P |
| Databáze: | OpenAIRE |
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