A comparative study of classic and HIV-viremic and aviremic AIDS Kaposi sarcoma
| Autor: | Grant, Rebecca, Fléchelles, Olivier, Tressières, Benoît, Dialo, Mama, Elenga, Narcisse, Mediamolle, Nicolas, Mallard, Adeline, Hebert, Jean-Christophe, Lachaume, Noémie, Couchy, Elvire, Hoen, Bruno, Fontanet, Arnaud, Séverin, David, Bessaoud, Faiza, Meftah, Nadia, Du Thanh, Aurelie, Tretarre, Brigitte, Guillot, Bernard, Makinson, Alain |
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| Přispěvatelé: | Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Université des Antilles (UA)-Etablissement français du don du sang [Montpellier]-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty [SDV]Life Sciences [q-bio] Immunology Gross motor skill Population HIV Infections 03 medical and health sciences 0302 clinical medicine Humans Immunology and Allergy Medicine Viremia 030212 general & internal medicine Toddler education Sarcoma Kaposi Retrospective Studies Acquired Immunodeficiency Syndrome Pregnancy education.field_of_study business.industry Gestational age medicine.disease 3. Good health 030104 developmental biology Infectious Diseases Autism France business Martinique Cohort study |
| Zdroj: | AIDS AIDS, Lippincott, Williams & Wilkins, 2021, 35 (3), pp.399-405. ⟨10.1097/QAD.0000000000002744⟩ |
| ISSN: | 0269-9370 |
| Popis: | International audience; Abstract Background In utero exposure to Zika virus (ZIKV) is known to be associated with birth defects. The impact of in utero ZIKV exposure on neurodevelopmental outcomes in early childhood remains unclear. The objective of this study was to determine the impact of in utero ZIKV exposure on neurodevelopment at 24 months of age among toddlers who were born normocephalic to women who were pregnant during the 2016 ZIKV outbreak in French territories in the Americas. Methods We conducted a population-based mother-child cohort study of women whose pregnancies overlapped with the 2016 ZIKV epidemic in Guadeloupe, Martinique, and French Guiana. Infants were included in this analysis if maternal ZIKV infection during pregnancy could be determined, the newborn had a gestational age ≥ 35 weeks, there were no abnormal transfontanelle cerebral ultrasound findings after delivery or no abnormal ultrasound findings on the last ultrasound performed during the third trimester of the mother’s pregnancy, there was an absence of microcephaly at birth, and the parent completed the 24-month neurodevelopment assessment of the infant at 24 months (± 1 month) of age. ZIKV exposure of the toddler was determined by evidence of maternal ZIKV infection during pregnancy. Neurodevelopment assessments included the Ages and Stages Questionnaire (ASQ) for five dimensions of general development—communication, gross motor, fine motor, problem solving, and personal-social skills; the Modified Checklist for Autism on Toddlers (M-CHAT) for behavior; and the French MacArthur Inventory Scales (IFDC) for French language acquisition. Results Between June 2018 and August 2019, 156 toddlers with and 79 toddlers without in utero ZIKV exposure completed neurodevelopment assessments. Twenty-four (15.4%) ZIKV-exposed toddlers and 20 (25.3%) ZIKV-unexposed toddlers had an ASQ result below the reference − 2SD cut-off ( P = 0.10) for at least one of the five ASQ dimensions. Conclusion In one of the largest population-based cohorts of in utero ZIKV-exposed, normocephalic newborns to date, there were minimal differences apparent in neurodevelopment outcomes at 24 months of age compared to ZIKV-unexposed toddlers at 24 months of age. Trial registration ClinicalTrials.gov, NCT02810210 . Registered 20 June 2016. |
| Databáze: | OpenAIRE |
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