Clinical Characteristics of a Nationwide Hospital-based Registry of Mild-to-Moderate Alzheimer's Disease Patients in Korea: A CREDOS (Clinical Research Center for Dementia of South Korea) Study
| Autor: | Do-Kwan Kim, SangYun Kim, Hae-Kwan Cheong, Yong S. Shim, Jae-Hong Lee, Kyung Ryeol Cha, Ji Young Kim, Hee Kyung Park, Duk L. Na, Chang Hyung Hong, Eun-Joo Kim, Seong Yoon Kim, Beoung-Chae Kim, Bon D. Ku, Young Chul Youn, Jun-Young Lee, Seol-Heui Han, Kee Hyung Park, Sang Won Seo, So Young Moon |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Far East Clinical Dementia Rating Neurological examination Disease Interviews as Topic Alzheimer Disease Risk Factors Surveys and Questionnaires Republic of Korea medicine Humans Dementia Registries Hospital-based study Radionuclide Imaging Socioeconomic status Demography Aged Aged 80 and over medicine.diagnostic_test business.industry Neuropsychology Brain General Medicine Alzheimer's disease Middle Aged medicine.disease Magnetic Resonance Imaging Multicenter study Hospitals Clinical research Caregivers Diabetes Mellitus Type 2 Hypertension Original Article Female business Neuroscience |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | With rapid population aging, the socioeconomic burden caused by dementia care is snowballing. Although a few community-based studies of Alzheimer's disease (AD) have been performed in Korea, there has never been a nationwide hospital-based study thereof. We aimed to identify the demographics and clinical characteristics of mild-to-moderate AD patients from the Clinical Research Center for Dementia of Korea (CREDOS) registry. A total of 1,786 patients were consecutively included from September 2005 to June 2010. Each patient underwent comprehensive neurological examination, interview for caregivers, laboratory investigations, neuropsychological tests, and brain MRI. The mean age was 74.0 yr and the female percentage 67.0%. The mean period of education was 7.1 yr and the frequency of early-onset AD (< 65 yr old) was 18.8%. Among the vascular risk factors, hypertension (48.9%) and diabetes mellitus (22.3%) were the most frequent. The mean score of the Korean version of Mini-Mental State Examination (K-MMSE) was 19.2 and the mean sum of box scores of Clinical Dementia Rating (CDR-SB) 5.1. Based on the well-structured, nationwide, and hospital-based registry, this study provides the unique clinical characteristics of AD and emphasizes the importance of vascular factors in AD in Korea. |
| Databáze: | OpenAIRE |
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