Ganglion Cell Complex Thickness and Macular Vessel Density Loss in Primary Open-Angle Glaucoma
| Autor: | James A. Proudfoot, Sasan Moghimi, Diya Yang, Rafaella C. Penteado, Christopher Bowd, Elham Ghahari, Robert N. Weinreb, Huiyuan Hou |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Retinal Ganglion Cells Aging genetic structures Glaucoma Neurodegenerative Eye Ophthalmology & Optometry Nerve Fibers 0302 clinical medicine Contrast (vision) Macula Lutea Prospective Studies Fluorescein Angiography Prospective cohort study Tomography media_common 0303 health sciences medicine.diagnostic_test Middle Aged Ganglion Open-Angle medicine.anatomical_structure Public Health and Health Services Female Glaucoma Open-Angle Tomography Optical Coherence medicine.medical_specialty Cell complex Open angle glaucoma Fundus Oculi media_common.quotation_subject Clinical Sciences Optic Disk Gonioscopy 03 medical and health sciences Clinical Research Opthalmology and Optometry Ophthalmology medicine Humans Eye Disease and Disorders of Vision Intraocular Pressure Aged 030304 developmental biology business.industry Neurosciences Retinal Vessels medicine.disease eye diseases Confidence interval Cross-Sectional Studies Optical Coherence 030221 ophthalmology & optometry sense organs Visual Fields business Follow-Up Studies |
| Zdroj: | Ophthalmology, vol 127, iss 8 |
| ISSN: | 0161-6420 |
| DOI: | 10.1016/j.ophtha.2019.12.030 |
| Popis: | PurposeTo characterize the change rate of ganglion cell complex (GCC) thickness and macular vessel density in healthy, preperimetric glaucoma and primary open-angle glaucoma (POAG) eyes.DesignProspective, longitudinal study.ParticipantsOne hundred thirty-nine eyes (23 healthy eyes, 36 preperimetric glaucoma eyes, and 80 POAG eyes) of 94 patients who had at least 3 visits were included from the Diagnostic Innovations in Glaucoma Study. The mean follow-up was 2.0 years for healthy eyes, 2.6 years for preperimetric glaucoma eyes, and 2.6 years for POAG eyes.MethodsOCT angiography (OCTA)-based vessel density and OCT-based structural thickness of the same 3×3-mm2 GCC scan slab were evaluated. The dynamic range-based normalized rates of vessel density and thickness change were calculated and compared within each diagnostic group. The association between the rates of thickness and vessel density change and potential factors were evaluated.Main outcome measuresThe rates of GCC thinning and macular vessel density loss.ResultsSignificant rates of GCC thinning and macular vessel density decrease were detectable in all diagnostic groups (all P < 0.05). In healthy eyes and preperimetric glaucoma eyes, the normalized rates of GCC thinning and macular vessel density decrease were comparable (all P > 0.1). In contrast, the normalized rate (mean, 95% confidence interval) of macular vessel density decrease in the POAG eyes (-7.12 [-8.36, -5.88]%/year) was significantly faster than GCC thinning (-2.13 [-3.35, -0.90]%/year; P < 0.001). In the POAG group, more than two thirds of the eyes showed faster macular vessel density decrease than GCC thinning; faster macular vessel density decrease rate was associated significantly with worse glaucoma severity (P= 0.037). The association between GCC thinning rate and glaucoma severity was not significant (P= 0.586). Intraocular pressure during follow-up significantly affected the rate of GCC thinning in all groups (all P < 0.05) but showed no association with the rate of macular vessel density decrease.ConclusionsBoth GCC thinning and macular vessel density decrease were detectable over time in all diagnostic groups. In POAG eyes, macular vessel density decrease was faster than GCC thinning and was associated with severity of disease. Macular vessel density is useful for evaluating glaucoma progression, particularly in more advanced disease. |
| Databáze: | OpenAIRE |
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