Controversial role of retinoids in ocular surface disease
| Autor: | Sayan Basu, Swapna S Shanbhag |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Eye Diseases 03 medical and health sciences Cellular and Molecular Neuroscience Retinoids Young Adult 0302 clinical medicine Psoriasis Medicine Humans Receptor Acne business.industry Actinic keratosis Epithelium Corneal medicine.disease Dermatology Sensory Systems Epithelium Squamous metaplasia Vitamin A deficiency stomatognathic diseases Ophthalmology medicine.anatomical_structure Rosacea Stevens-Johnson Syndrome Acute Disease 030221 ophthalmology & optometry Female Ophthalmic Solutions business Conjunctiva 030217 neurology & neurosurgery |
| Zdroj: | The British journal of ophthalmology. 103(8) |
| ISSN: | 1468-2079 |
| Popis: | Retinoids are chemical derivatives of vitamin A or synthetic compounds that are structurally or functionally similar to it.1 In the body, retinoids bind to specific receptors leading to the activation of DNA regions involved in regulating epithelial cell growth, differentiation and apoptosis. Retinoids are widely used in dermatology and approved for clinical use in the treatment of acne, rosacea, psoriasis, lichen planus and ichthyosis.1 Retinoids have also shown efficacy in reversing photoageing, preventing precancerous lesions like actinic keratosis from progressing, and in reducing the risk of skin cancers in solid organ transplant recipients.1 However, the role of retinoids in ophthalmology has been controversial. In the 1980s ocular surface disease emerged as a potential therapeutic target, since vitamin A deficiency was known to cause epithelial squamous metaplasia and glandular atrophy.2 The first study included a variety of dry eye disorders including keratoconjunctivitis sicca, Stevens-Johnson syndrome (SJS), mucous membrane pemphigoid (MMP) and radiation-induced dryness. The preliminary results were extremely encouraging and showed reversal of squamous metaplasia or keratinisation on impression cytology.2 Unfortunately, … |
| Databáze: | OpenAIRE |
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