Asymmetric Michael Additions of α-Nitrocyclohexanone to Aryl Nitroalkenes Catalyzed by Natural Amino Acid-Derived Bifunctional Thioureas
| Autor: | Manuel Jörres, Carsten Bolm, Ingo Schiffers, Iuliana Atodiresei |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Aspartic Acid Pyrrolidines Molecular Structure Aryl Organic Chemistry Thiourea Glutamic Acid Stereoisomerism Alkenes Nitro Compounds Biochemistry Catalysis Amino acid chemistry.chemical_compound Piperidines chemistry Organic chemistry Amino Acids Physical and Theoretical Chemistry Bifunctional |
| Zdroj: | Organic Letters. 14:4518-4521 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/ol302005f |
| Popis: | A series of new thiourea catalysts prepared from natural amino acids have been applied in organocatalytic asymmetric Michael additions of α-nitrocyclohexanone to nitroalkenes. The resulting addition products are formed with excellent enantioselectivities (up to an er of 98:2) in good yields (up to 90%). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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