Macroscopic tumor volume of malignant glioma determined by contrast-enhanced magnetic resonance imaging with and without magnetization transfer contrast
| Autor: | Gerhard van Kaick, Rita Engenhart-Cabilic, Marco Essig, Gunnar Brix, Michael V. Knopp, Wolfgang Schreiber, Hans Hawighorst |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Gadolinium DTPA Male medicine.medical_treatment Contrast effect Brachytherapy Biomedical Engineering Biophysics Contrast Media Gadolinium Radiosurgery Nuclear magnetic resonance Glioma medicine Organometallic Compounds Humans Radiology Nuclear Medicine and imaging Magnetization transfer Prospective Studies Contrast-enhanced Magnetic Resonance Imaging medicine.diagnostic_test business.industry Chemistry Brain Neoplasms Brain Magnetic resonance imaging Middle Aged Pentetic Acid medicine.disease Magnetic Resonance Imaging Radiation therapy Female Nuclear medicine business |
| Zdroj: | Magnetic resonance imaging. 14(10) |
| ISSN: | 0730-725X |
| Popis: | The purposes of this study were to compare the conspicuity and lesion volume of contrast-enhancing macroscopic malignant glioma determined by postcontrast magnetic resonance (MR) imaging with and without magnetization transfer (MT) saturation, and to discuss possible implications for radiotherapy planning. Nineteen patients (age 24-60 years) with histologically proven malignant glioma were prospectively examined by MR imaging. After the administration of gadolinium dimeglumine (0.1 mmol/kg body weight), the lesions were imaged with an MT-weighted FLASH (fast, low-angle shot) pulse sequence and with a conventional T1-weighted spin-echo (SE) sequence without MT saturation. The mean tumor volumes of gliomas measured on MT-weighted FLASH images were significantly (p.01) larger than those obtained from T1-weighted SE images (45 +/- 15 cm3 vs. 33 +/- 10 cm3). The mean contrast-to-noise ratio of enhancing lesions on MT-weighted FLASH was 48 +/- 14 compared with 30 +/- 14 on SE images, representing a significant (p.01) improvement. We conclude that the volume of contrast enhancement of malignant glioma identified on MT-weighted FLASH images represents the area of disrupted blood-brain barrier. If this volume of subtle contrast enhancement is caused by tumor infiltration and represents the boost target volume for stereotactic radiosurgery or brachytherapy, MT-weighted FLASH images would be better than T1-weighted SE images to define these volumes. These improved delineation of areas at highest risk for recurrence following radiation therapy should enhance the efficacy of treatment planning for high-boost therapy. |
| Databáze: | OpenAIRE |
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