Guidelines for the provision of nutrition support therapy in the adult critically ill patient: The American Society for Parenteral and Enteral Nutrition
| Autor: | Todd W. Rice, Carol L. Braunschweig, Liam McKeever, Angela L. Bingham, Jayshil J. Patel, Michele McCall, Charlene Compher |
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| Rok vydání: | 2022 |
| Předmět: |
Parenteral Nutrition
medicine.medical_specialty Nutrition and Dietetics Critical Care Nutritional Support business.industry Critical Illness Medicine (miscellaneous) Guideline Intensive care unit law.invention Study heterogeneity Enteral Nutrition Parenteral nutrition Randomized controlled trial law medicine Forest plot Humans Clinical significance Medical prescription Intensive care medicine business |
| Zdroj: | Journal of Parenteral and Enteral Nutrition. 46:12-41 |
| ISSN: | 1941-2444 0148-6071 |
| DOI: | 10.1002/jpen.2267 |
| Popis: | Background New randomized controlled trials have been conducted since publication of the 2016 ASPEN/SCCM critical care nutrition guideline. This guideline updates recommendations for foundational questions central to critical care nutrition support. Methods The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) process was used to develop and summarize evidence for clinical practice recommendations. Clinical outcomes were assessed for (1) higher vs lower energy dose (2) higher vs lower protein dose (3) exclusive isocaloric PN vs EN (4) supplemental PN (SPN) plus EN vs EN alone (5a) mixed oil lipid injectable emulsions (ILE) vs soybean oil, and (5b) Fish oil (FO) containing ILE vs non-FO ILE. To assess safety, weight based energy intake was plotted against hospital mortality when study heterogeneity precluded meaningful Forest plot inferences. Results Between 1/1/2001 and 07/15/2020, 2,320 citations were identified and data were abstracted from 39 trials, including 20,578 participants. Patients receiving FO had decreased pneumonia rates of uncertain clinical significance. Otherwise, there were no differences for any outcome in any question. Due to lack in certainty regarding harm, the energy prescription recommendation was decreased to 12-25kcal/kg/day. Conclusion No differences in clinical outcomes were identified among numerous nutritional interventions, including higher energy or protein intake, isocaloric PN or EN, supplemental PN, or different ILEs. As more consistent critical care nutrition support data become available, more precise recommendations will be possible. In the meantime, clinical judgment and close monitoring are needed. This paper was approved by the ASPEN Board of Directors. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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