Thymoma-associated multiorgan autoimmunity treated with multimodal therapy including extracorporeal photopheresis
| Autor: | John G. Zampella, Abhishek Gami, Manisha J. Loss, Chikoti M. Wheat, Judy Doong |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Thymoma ECP extracorporeal photopheresis extracorporeal photopheresis medicine.medical_treatment Case Report chemical and pharmacologic phenomena Dermatology GVHD graft-versus-host disease medicine.disease_cause Gastroenterology Autoimmunity Prednisone hemic and lymphatic diseases Internal medicine Extracorporeal Photopheresis IVIg intravenous immunoglobulin medicine immunosuppression business.industry autoimmunity Multimodal therapy Immunosuppression thymoma medicine.disease TAMA thymoma-associated multiorgan autoimmunity thymoma-associated multiorgan autoimmunity Radiation therapy surgical procedures operative Graft-versus-host disease RL1-803 business medicine.drug |
| Zdroj: | JAAD Case Reports, Vol 16, Iss, Pp 141-143 (2021) JAAD Case Reports |
| ISSN: | 2352-5126 |
| Popis: | Patients with malignant thymomas are susceptible to the development of graft-versus-host disease (GVHD)–like disease known as thymoma-associated multiorgan autoimmunity (TAMA). The proposed mechanism of this paraneoplastic phenomenon is a breakdown in the immune regulatory function of the thymus and subsequent activation of T cells. Here, we report a novel case of a patient with TAMA who, following surgical resection and radiation therapy, successfully underwent treatment with a combination of extracorporeal photopheresis (ECP), intravenous immunoglobulin (IVIg), cyclosporine, and prednisone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|