Epstein-Barr virus is associated with grey matter atrophy in multiple sclerosis
| Autor: | Cosimo Maggiore, Maria Antonietta Tommasi, Alessio Bratina, Marino Zorzon, Robert Zivadinov, Murali Ramanathan, Maurizia Serafin, Attilio Grop, A. Bosco, Bianca Weinstock-Guttman, Bhooma Srinivasaraghavan |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Epstein-Barr Virus Infections Herpesvirus 4 Human Pathology medicine.medical_specialty Multiple Sclerosis Grey matter Antibodies Viral medicine.disease_cause White matter Lesion Atrophy Antigen Image Processing Computer-Assisted Humans Medicine Aged Retrospective Studies medicine.diagnostic_test business.industry Multiple sclerosis Brain Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging Epstein–Barr virus Psychiatry and Mental health medicine.anatomical_structure Female Surgery Neurology (clinical) medicine.symptom business |
| Zdroj: | Journal of Neurology, Neurosurgery & Psychiatry. 80:620-625 |
| ISSN: | 0022-3050 |
| DOI: | 10.1136/jnnp.2008.154906 |
| Popis: | The aim of the study was to determine whether the presence of anti-Epstein-Barr virus (EBV) antibodies is associated with MRI measures of brain injury and neurodegeneration in patients with multiple sclerosis (MS).135 patients with MS (86 women, 49 men) underwent brain MRI and testing for antibodies against EBV. MRI measurements included gadolinium enhancing lesion volume, T1 and T2 lesion volumes and fractions of whole brain parenchyma (BPF), white matter and grey matter (GMF). The anti-EBV panel included anti-EBV early antigen IgG, anti-EBV nuclear antigen IgG and anti-EBV viral capsid antigen (VCA) IgG levels. The relationships between antibody levels and MRI measurements were assessed in regression analysis. Repeat measurements of anti-EBV VCA IgG and MRI measures were available for a subset of 50 patients after a mean follow-up of 3.1 years.GMF (R(2) = 0.24 for overall model, p = 0.002) and BPF (R(2) = 0.39 for overall model, p0.001) showed negative associations with anti-EBV-VCA IgG levels. A greater decline in BPF over 3 years was significantly associated with increased 3 years prior time point anti-EBV VCA IgG levels (p0.001).The results suggest that the presence of anti-EBV antibodies is associated with MRI markers of GM atrophy in MS and with increased loss of brain volume over 3 years. |
| Databáze: | OpenAIRE |
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